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Christy A. Cheever
Researcher at University of Liège
Publications - 1
Citations - 305
Christy A. Cheever is an academic researcher from University of Liège. The author has contributed to research in topics: Binding site & Oxyanion hole. The author has an hindex of 1, co-authored 1 publications receiving 291 citations.
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Crystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor.
Nestor O. Concha,Cheryl A. Janson,Pam Rowling,Stewart C. Pearson,Christy A. Cheever,Brian Peter SmithKline Beecham Pharm Clarke,Ceri Lewis,Moreno Galleni,Jean-Marie Frere,David J. Payne,Bateson John Hargreaves,Sherin S. Abdel-Meguid +11 more
TL;DR: A unique mode of binding of the mercaptocarboxylate inhibitor in the enzyme active site provides a binding model for metallo beta-lactamase inhibition with utility for future drug design.