S
Sherin S. Abdel-Meguid
Researcher at University of Liège
Publications - 5
Citations - 309
Sherin S. Abdel-Meguid is an academic researcher from University of Liège. The author has contributed to research in topics: Cathepsin K & Binding site. The author has an hindex of 2, co-authored 5 publications receiving 295 citations.
Papers
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Journal ArticleDOI
Crystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor.
Nestor O. Concha,Cheryl A. Janson,Pam Rowling,Stewart C. Pearson,Christy A. Cheever,Brian Peter SmithKline Beecham Pharm Clarke,Ceri Lewis,Moreno Galleni,Jean-Marie Frere,David J. Payne,Bateson John Hargreaves,Sherin S. Abdel-Meguid +11 more
TL;DR: A unique mode of binding of the mercaptocarboxylate inhibitor in the enzyme active site provides a binding model for metallo beta-lactamase inhibition with utility for future drug design.
Patent
Novel imp-1 metallo beta-lactamase enzyme
TL;DR: In this paper, a novel Pseudomonas aeruginosa IMP-1 metallo beta-lactamase native crystalline structure and a new PAM complex with the inhibitor SB-252619 were identified.
Book ChapterDOI
Rational Approaches to Inhibition of Human Osteoclast Cathepsin K and Treatment of Osteoporosis
Sherin S. Abdel-Meguid,Baoguang Zhao,Ward W. Smith,Cheryl A. Hanson,Judith LaLonde,Thomas Joseph Carr,Karla J. D'Alessio,Michael S. McQueney,H.-J. Oh,Scott K. Thompson,Daniel F. Veber,Dennis S. Yamashita +11 more