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Chuan Chou Tu
Researcher at Mackay Memorial Hospital
Publications - 19
Citations - 537
Chuan Chou Tu is an academic researcher from Mackay Memorial Hospital. The author has contributed to research in topics: Cancer cell & Cell growth. The author has an hindex of 11, co-authored 19 publications receiving 376 citations.
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Journal ArticleDOI
Oxaliplatin resistance in colorectal cancer cells is mediated via activation of ABCG2 to alleviate ER stress induced apoptosis.
Hsi Hsien Hsu,Ming Cheng Chen,Rathinasamy Baskaran,Yueh Min Lin,Cecilia Hsuan Day,Yi Jiun Lin,Chuan Chou Tu,V. Vijaya Padma,Wei Wen Kuo,Chih Yang Huang +9 more
TL;DR: Development of multi drug resistance in OXA‐R cells was confirmed by exposing the resistance cells to oxaliplatin, 5‐FU, and doxorubicin, and in vivo studies in nude mice also confirms the same.
Journal ArticleDOI
Thymoquinone induces caspase-independent, autophagic cell death in cpt-11-resistant LoVo colon cancer via mitochondrial dysfunction and activation of JNK and p38
Ming Cheng Chen,Nien Hung Lee,Hsi Hsien Hsu,Hsi Hsien Hsu,Tsung Jung Ho,Chuan Chou Tu,Dennis Jine Yuan Hsieh,Yueh Min Lin,Li Mien Chen,Wei Wen Kuo,Chih Yang Huang +10 more
TL;DR: Thymoquinone resulted in caspase-independent, autophagic cell death via MOMP and activation of JNK and p38 in CPT-11-R LoVo colon cancer cells.
Journal ArticleDOI
Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation.
Hsi Hsien Hsu,Ming Cheng Chen,Cecilia Hsuan Day,Yueh Min Lin,Shin Yi Li,Chuan Chou Tu,Viswanadha Vijaya Padma,Hui Nung Shih,Wei Wen Kuo,Chih Yang Huang +9 more
TL;DR: TQ inhibits LoVo cancer cell growth and migration, and this result highlights the therapeutic advantage of using TQ in combination therapy against colorectal cancer.
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FOXC1 Regulation of miR-31-5p Confers Oxaliplatin Resistance by Targeting LATS2 in Colorectal Cancer.
Hsi Hsien Hsu,Wei Wen Kuo,Hui Nung Shih,Sue Fei Cheng,Ching Kuo Yang,Ming Cheng Chen,Chuan Chou Tu,Vijaya Padma Viswanadha,Po Hsiang Liao,Chih Yang Huang +9 more
TL;DR: A novel drug-resistance mechanism in which the transcription factor FOXC1 binds to the miR-31 promoter to increase the expression of miR31-5p and regulate LATS2 expression, resulting in cancer cell resistance to OXA is revealed.
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CXCL2/CXCR2 axis induces cancer stem cell characteristics in CPT-11-resistant LoVo colon cancer cells via Gαi-2 and Gαq/11.
Ming Cheng Chen,Ming Cheng Chen,Rathinasamy Baskaran,Nien Hung Lee,Hsi Hsien Hsu,Hsi Hsien Hsu,Tsung Jung Ho,Chuan Chou Tu,Yueh Min Lin,Vijaya Padma Viswanadha,Wei Wen Kuo,Chih Yang Huang,Chih Yang Huang +12 more
TL;DR: CXCL2–CXCR2 axis mediates through Gαi‐2 and Gαq/11 to promote tumorigenesis and contributes to CSC properties of CPT‐11‐R LoVo cells.