C
Chun-Rong Chen
Researcher at University of California, Los Angeles
Publications - 50
Citations - 1386
Chun-Rong Chen is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Thyrotropin receptor & Graves' disease. The author has an hindex of 21, co-authored 50 publications receiving 1318 citations. Previous affiliations of Chun-Rong Chen include Cedars-Sinai Medical Center.
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Journal ArticleDOI
The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim
Chun-Rong Chen,Pavel N. Pichurin,Yuji Nagayama,Francesco Latrofa,Basil Rapoport,Sandra M. McLachlan +5 more
TL;DR: Goiter and hyperthyroidism occur to a much greater extent when the adenovirus expresses the free A subunit as opposed to a genetically modified TSHR that cleaves minimally into subunits, and new insight is provided into the etiology of Graves disease.
Journal ArticleDOI
Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor
Gregorio D. Chazenbalk,Pavel N. Pichurin,Chun-Rong Chen,Francesco Latrofa,Alan P. Johnstone,Sandra M. McLachlan,Basil Rapoport +6 more
TL;DR: Evidence supports the concept that A subunit shedding either initiates or amplifies the autoimmune response to the TSHR, thereby causing Graves disease in genetically susceptible individuals.
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The Thyrotropin Receptor Hinge Region Is Not Simply a Scaffold for the Leucine-Rich Domain but Contributes to Ligand Binding and Signal Transduction
TL;DR: The data support the concept that the TSHR hinge contributes significantly to ligand binding affinity and signal transduction and Residues within the hinge, particularly between positions 371-384, appear involved in ectodomain inverse agonist activity.
Journal ArticleDOI
Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies.
Chun-Rong Chen,Sepehr Hamidi,Helen Braley-Mullen,Yuji Nagayama,Catherine Bresee,Holly A. Aliesky,Basil Rapoport,Sandra M. McLachlan +7 more
TL;DR: A novel aspect of murine and human thyroid autoimmunity, namely breaking B cell self-tolerance occurs first for Tg and subsequently for TPO, is demonstrated.
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A full biological response to autoantibodies in Graves' disease requires a disulfide-bonded loop in the thyrotropin receptor N terminus homologous to a laminin epidermal growth factor-like domain.
TL;DR: Am amino acid homology between the cysteine-rich N terminus of the thyrotropin receptor (TSHR) ectodomain and epidermal growth factor-like repeats in the laminin γ1 chain suggests conformational similarity between the two molecules and raises the possibility of molecular mimicry in the pathogenesis of Graves' disease.