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Chunpu Li
Researcher at Shanghai University
Publications - 13
Citations - 399
Chunpu Li is an academic researcher from Shanghai University. The author has contributed to research in topics: Peptidomimetic & Metastasis. The author has an hindex of 7, co-authored 13 publications receiving 235 citations. Previous affiliations of Chunpu Li include University of South Florida.
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Journal ArticleDOI
Tanshinone IIA inhibits β-catenin/VEGF-mediated angiogenesis by targeting TGF-β1 in normoxic and HIF-1α in hypoxic microenvironments in human colorectal cancer
Hua Sui,Jihui Zhao,Lihong Zhou,Haotian Wen,Wanli Deng,Chunpu Li,Qing Ji,Xuan Liu,Yuanyuan Feng,Ni Chai,Qibo Zhang,Jianfeng Cai,Qi Li +12 more
TL;DR: Tan IIA sodium sulfonate exhibits anti-angiogenesis activity in CRC patients by reducing levels of angiogenin, VEGF and bFGF expression and strengthens support for the use of Tan IIA as an angiogenesis inhibitor.
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Inhibition of β-catenin/B cell lymphoma 9 protein−protein interaction using α-helix–mimicking sulfono-γ-AApeptide inhibitors
Peng Sang,Min Zhang,Yan Shi,Chunpu Li,Chunpu Li,Sami Abdulkadir,Qi Li,Haitao Ji,Jianfeng Cai +8 more
TL;DR: A series of unprecedented helical sulfono-γ-AApeptides that mimic the binding mode of the α-helical HD2 domain of B Cell Lymphoma 9 (BCL9) and disrupt cancer-related β-catenin/ BCL9 protein–protein interaction in cells with excellent potency and specificity are designed.
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Development of EGFR-targeted evodiamine nanoparticles for the treatment of colorectal cancer.
Chunpu Li,Gang Cai,Daqian Song,Ruixuan Gao,Peng Teng,Lihong Zhou,Qing Ji,Hua Sui,Jianfeng Cai,Qi Li,Yan Wang +10 more
TL;DR: In vivo studies show that the GE11-Evo-NPs exhibited much greater potency than other control groups in inhibiting CRC invasion and metastasis, tumor volume, and growth in nude mice, leading to a significantly prolonged tumor-bearing survival duration (P < 0.01).
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Novel bis-cyclic guanidines as potent membrane-active antibacterial agents with therapeutic potential
Peng Teng,Alekhya Nimmagadda,Ma Su,Yuzhu Hong,Ning Shen,Chunpu Li,Chunpu Li,Ling-Yu Tsai,Jessica Cao,Qi Li,Jianfeng Cai +10 more
TL;DR: A class of small dimeric cyclic guanidine derivatives which display potent antibacterial activity against both multidrug-resistant Gram-negative and Gram-positive bacteria are designed.
Journal ArticleDOI
Development of Bis-cyclic Imidazolidine-4-one Derivatives as Potent Antibacterial Agents
Minghui Wang,Ruixuan Gao,Mengmeng Zheng,Peng Sang,Chunpu Li,Chunpu Li,En Zhang,En Zhang,Qi Li,Jianfeng Cai +9 more
TL;DR: Mechanistic and time-kill kinetics and drug resistance studies suggested that the most potent compound 3 could not only eliminate the bacteria rapidly, but also exhibit low probability of drug resistance in MRSA over many passages.