Chunxia Luo

TL;DR: The brain-iron concentration in the SN correlated with UPDRS motor score, indicating that iron concentration can function as an in vivo biomarker to objectively evaluate the status of PD.

TL;DR: It is suggested that ALS is multisystem degeneration involving both the widespread cortices and the underlying WM fibers, and GM and WM changes might play distinct roles in the disease progression.

TL;DR: Evidence is provided for the precentral degeneration and cerebellar compensation in ALS, and the involvement of WM alterations in mediating the relationship between pathologies of the primary motor cortex and Cerebellum, which may contribute to a better understanding of the pathophysiology of ALS.

TL;DR: Network-level evidence is provided for the concept that ALS is a multisystem disorder with a cerebral involvement extending beyond the motor areas with a regularized architecture evidenced by increased path length, clustering coefficient, small-world index, and modularity.

TL;DR: Using fixel‐based analysis, decreased FD, FC and FDC were found in the CST and CC in ALS and were associated with the clinical severity in ALS.