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Cicely W. Fadel
Researcher at Wyss Institute for Biologically Inspired Engineering
Publications - 10
Citations - 498
Cicely W. Fadel is an academic researcher from Wyss Institute for Biologically Inspired Engineering. The author has contributed to research in topics: Medicine & Microbiome. The author has an hindex of 2, co-authored 7 publications receiving 251 citations. Previous affiliations of Cicely W. Fadel include Harvard University & Beth Israel Deaconess Medical Center.
Papers
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Journal ArticleDOI
A Complex Human-Gut Microbiome Cultured in an Anaerobic Intestine-on-a-Chip
Sasan Jalili-Firoozinezhad,Sasan Jalili-Firoozinezhad,Francesca S. Gazzaniga,Francesca S. Gazzaniga,Elizabeth Calamari,Diogo M. Camacho,Cicely W. Fadel,Amir Bein,Ben Swenor,Bret Nestor,Michael J. Cronce,Alessio Tovaglieri,Alessio Tovaglieri,Oren Levy,Katherine E. Gregory,Katherine E. Gregory,David T. Breault,David T. Breault,Joaquim M. S. Cabral,Dennis L. Kasper,Richard M. Novak,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +23 more
TL;DR: The extended coculture of living human intestinal epithelium with stable communities of aerobic and anaerobic human gut microbiota is shown, using a microfluidic intestine-on-a-chip that permits the control and real-time assessment of physiologically relevant oxygen gradients.
Journal ArticleDOI
Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip.
Amir Bein,Seongmin Kim,Girija Goyal,Wuji Cao,Cicely W. Fadel,Arash Naziripour,Sanjay Sharma,Ben Swenor,Nina LoGrande,Atiq Nurani,Vincent N. Miao,Andrew W Navia,Andrew W Navia,Carly G. K. Ziegler,José Ordovas Montañes,José Ordovas Montañes,José Ordovas Montañes,Pranav Prabhala,Min Sun Kim,Rachelle Prantil-Baun,Melissa Rodas,Amanda Jiang,Lucy R. O’Sullivan,Gladness Tillya,Alex K. Shalek,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +27 more
TL;DR: In this article, a human intestine-on-a-chip (Intestine Chip) microfluidic culture device was used to study host cellular and inflammatory responses to infection with NL63 coronavirus.
Posted ContentDOI
Complex human gut microbiome cultured in anaerobic human intestine chips
Sasan Jalili-Firoozinezhad,Francesca S. Gazzaniga,Elizabeth Calamari,Diogo M. Camacho,Cicely W. Fadel,Bret Nestor,Michael J. Cronce,Alessio Tovaglieri,Oren Levy,Katherine E. Gregory,David T. Breault,Cabral Jms,Dennis L. Kasper,Richard M. Novak,Donald E. Ingber,Donald E. Ingber +15 more
TL;DR: A human Organ-on-a-Chip (Organ Chip) microfluidic platform that permits control and real-time assessment of physiologically-relevant oxygen gradients, and which enables co-culture of living human intestinal epithelium with stable communities of aerobic and anaerobic human gut microbiota is described.
Journal ArticleDOI
Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction
Amir Bein,Cicely W. Fadel,Benjamin D. Swenor,Wuji Cao,Rani K. Powers,Diogo M. Camacho,Arash Naziripour,Andrew S Parsons,Nina LoGrande,Sanjay Sharma,S. Kim,Sasan Jalili-Firoozinezhad,Jennifer Grant,David T. Breault,Junaid Iqbal,Asad Ali,Lee A. Denson,Sean R. Moore,Rachelle Prantil-Baun,Girija Goyal,Donald E. Ingber +20 more
TL;DR: In this article , essential genotypic and phenotypic features of EED-associated intestinal injury can be reconstituted in a human intestine-on-a-chip lined by organoid-derived intestinal epithelial cells from patients with EED and cultured in nutrient-deficient medium lacking niacinamide and tryptophan.
Book ChapterDOI
Establishment of a Modular Anaerobic Human Intestine Chip.
Sasan Jalili-Firoozinezhad,Amir Bein,Francesca S. Gazzaniga,Cicely W. Fadel,Cicely W. Fadel,Richard M. Novak,Donald E. Ingber,Donald E. Ingber +7 more
TL;DR: In this paper, a protocol for culturing human organ-on-a-chip (Organ Chip) microfluidic devices lined by human patient-derived primary intestinal epithelium in the presence of a physiologically relevant transluminal hypoxia gradient that enables their coculture with hundreds of different living aerobic and anaerobic bacteria found within the human gut microbiome.