A
Alessio Tovaglieri
Researcher at Wyss Institute for Biologically Inspired Engineering
Publications - 20
Citations - 2052
Alessio Tovaglieri is an academic researcher from Wyss Institute for Biologically Inspired Engineering. The author has contributed to research in topics: Microbiome & Stem cell. The author has an hindex of 13, co-authored 19 publications receiving 1317 citations. Previous affiliations of Alessio Tovaglieri include Harvard University & Boston Children's Hospital.
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Journal ArticleDOI
Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids
Magdalena Kasendra,Alessio Tovaglieri,Alessio Tovaglieri,Alexandra Sontheimer-Phelps,Alexandra Sontheimer-Phelps,Sasan Jalili-Firoozinezhad,Sasan Jalili-Firoozinezhad,Amir Bein,Angeliki Chalkiadaki,William Scholl,Cheng Zhang,Hannah Rickner,Camilla A. Richmond,Hu Li,David T. Breault,David T. Breault,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +18 more
TL;DR: The Intestine Chip may be useful as a research tool for applications where normal intestinal function is crucial, including studies of metabolism, nutrition, infection, and drug pharmacokinetics, as well as personalized medicine.
Journal ArticleDOI
A Complex Human-Gut Microbiome Cultured in an Anaerobic Intestine-on-a-Chip
Sasan Jalili-Firoozinezhad,Sasan Jalili-Firoozinezhad,Francesca S. Gazzaniga,Francesca S. Gazzaniga,Elizabeth Calamari,Diogo M. Camacho,Cicely W. Fadel,Amir Bein,Ben Swenor,Bret Nestor,Michael J. Cronce,Alessio Tovaglieri,Alessio Tovaglieri,Oren Levy,Katherine E. Gregory,Katherine E. Gregory,David T. Breault,David T. Breault,Joaquim M. S. Cabral,Dennis L. Kasper,Richard M. Novak,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +23 more
TL;DR: The extended coculture of living human intestinal epithelium with stable communities of aerobic and anaerobic human gut microbiota is shown, using a microfluidic intestine-on-a-chip that permits the control and real-time assessment of physiologically relevant oxygen gradients.
Journal ArticleDOI
Microfluidic Organ-on-a-Chip Models of Human Intestine.
Amir Bein,Woojung Shin,Sasan Jalili-Firoozinezhad,Sasan Jalili-Firoozinezhad,Min Hee Park,Alexandra Sontheimer-Phelps,Alexandra Sontheimer-Phelps,Alessio Tovaglieri,Alessio Tovaglieri,Angeliki Chalkiadaki,Hyun-Jung Kim,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +13 more
TL;DR: How microfluidic Intestine Chips offer new capabilities not possible with conventional culture systems or organoid cultures, including the ability to analyze contributions of individual cellular, chemical, and physical control parameters one-at-a-time is described.
Journal ArticleDOI
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B
Liang Tao,Jie Zhang,Jie Zhang,Paul Meraner,Alessio Tovaglieri,Xiaoqian Wu,Ralf Gerhard,Xinjun Zhang,William B. Stallcup,Ji Miao,Ji Miao,Xi He,Xi He,Julian G. Hurdle,David T. Breault,David T. Breault,Abraham L. Brass,Min Dong,Min Dong +18 more
TL;DR: FZDs are established as physiologically relevant receptors for TcdB in the colonic epithelium by carrying out CRISPR–Cas9-mediated genome-wide screens and identifying the members of the Wnt receptor frizzled family (FzDs) as TCDB receptors.
Journal ArticleDOI
Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology.
Alexandra Sontheimer-Phelps,David B. Chou,Alessio Tovaglieri,Thomas C. Ferrante,Taylor Duckworth,Cicely Fadel,Viktoras Frismantas,Arlene D. Sutherland,Sasan Jalili-Firoozinezhad,Magdalena Kasendra,Eric Stas,James C. Weaver,Camilla A. Richmond,Oren Levy,Rachelle Prantil-Baun,David T. Breault,Donald E. Ingber +16 more
TL;DR: This study shows the production of colonic mucus with a physiologically relevant bilayer structure in vitro, which can be analyzed in real time noninvasively and may offer a new preclinical tool to analyze the role of mucus in human intestinal homeostasis as well as diseases.