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Cinzia Allegrucci
Researcher at University of Nottingham
Publications - 51
Citations - 3393
Cinzia Allegrucci is an academic researcher from University of Nottingham. The author has contributed to research in topics: Stem cell & Embryonic stem cell. The author has an hindex of 25, co-authored 46 publications receiving 3077 citations. Previous affiliations of Cinzia Allegrucci include University of Perugia & Health Science University.
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Journal ArticleDOI
DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status
Kevin D. Sinclair,Cinzia Allegrucci,Ravinder J. Singh,David S. Gardner,Sonia Sebastian,J. Bispham,Alexandra Thurston,John F. Huntley,William D. Rees,Christopher A. Maloney,Richard G. Lea,Jim Craigon,T.G. McEvoy,Lorraine E. Young +13 more
TL;DR: The data provide the first evidence that clinically relevant reductions in specific dietary inputs to the methionine/folate cycles during the periconceptional period can lead to widespread epigenetic alterations to DNA methylation in offspring, and modify adult health-related phenotypes.
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Improved Human Embryonic Stem Cell Embryoid Body Homogeneity and Cardiomyocyte Differentiation from a Novel V-96 Plate Aggregation System Highlights Interline Variability
Paul W. Burridge,David A. Anderson,Helen Priddle,Maria D. Barbadillo Muñoz,Sarah Chamberlain,Cinzia Allegrucci,Lorraine E. Young,Chris Denning +7 more
TL;DR: A high‐throughput, forced‐aggregation system involving centrifugation of defined numbers of hESCs in V‐96 plates (V‐96FA) was developed to examine formation, growth, and subsequent cardiomyocyte differentiation from >22,000 EBs and identified HUES‐7 as a line that can respond toCardiomyogenic stimulation.
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Differences between human embryonic stem cell lines
Cinzia Allegrucci,L.E. Young +1 more
TL;DR: The evidence for differences between lines is reviewed, focusing on studies of pluripotency marker molecules, transcriptional profiling, genetic stability and epigenetic stability, for which there is most evidence.
Journal ArticleDOI
Epigenetics and the germline
TL;DR: The consequences of epigenetic perturbation are discussed and new in vitro models which may allow further understanding of a difficult developmental period to study, especially in the human, are highlighted.
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Principles of early human development and germ cell program from conserved model systems
Toshihiro Kobayashi,Toshihiro Kobayashi,Haixin Zhang,Walfred W. C. Tang,Walfred W. C. Tang,Naoko Irie,Naoko Irie,Sarah L. Withey,Doris Klisch,Anastasiya Sybirna,Anastasiya Sybirna,Sabine Dietmann,Sabine Dietmann,David A. Contreras,Robert Webb,Cinzia Allegrucci,Ramiro Alberio,M. Azim Surani,M. Azim Surani +18 more
TL;DR: Porcine PGCs originate from the posterior pre-primitive-streak competent epiblast by sequential upregulation of SOX17 and BLIMP1 in response to WNT and BMP signalling, and this model together with human and monkey in vitro models simulating peri-gastrulation development is used to show the conserved principles of epiblasts development for competency for primordial germ cell fate.