Clarence P. Cain

TL;DR: The novel sequential imaging of rapidly evolving macular lesions with optical coherence tomography provides new insight into the patterns of acute tissue response by cross-sectional layer.

TL;DR: In this paper, single laser pulses at visible wavelengths were placed within the macular area of live rhesus monkey eyes at varying pulse energies at five pulsewidths (4 ns, 60 ps, 3 ps, 600 fs, and 90 fs) and a probit analysis was performed for the dosage, causing 50% probability for damage (ED50) as well as the 95% fiducial intervals for ED50.

TL;DR: In this paper, the authors present results of calculations and measurements for laser-induced breakdown (LIB), bubble generation, and self-focusing within the eye, and conclude that in the femtosecond pulsewidth regime for visible laser pulses, LIB and self focusing are contributing factors in lesion thresholds measured.

TL;DR: In this article, the authors extend the application of the z-scan technique to determine the nonlinear refractive index (n(2)) for human and rabbit vitreous humor, water, and physiological saline.

TL;DR: Laser pulse widths less than 1 nsec in the near-IR are capable of producing visible lesions in rhesus monkey eyes with pulse energies between 5 and 1 microJ, and as with visible wavelengths, FA is not as sensitive in determining threshold levels as is visually observing the retina through a fundus camera.