C
Claridge Tdw.
Researcher at University of Oxford
Publications - 5
Citations - 84
Claridge Tdw. is an academic researcher from University of Oxford. The author has contributed to research in topics: Enantioselective synthesis & Amide. The author has an hindex of 4, co-authored 5 publications receiving 46 citations. Previous affiliations of Claridge Tdw. include John Radcliffe Hospital.
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Metabolomics reveals distinct, antibody-independent, molecular signatures of MS, AQP4-antibody and MOG-antibody disease.
Maciej Juryńczyk,Maciej Juryńczyk,Fay Probert,Tianrong Yeo,George Tackley,Claridge Tdw.,Ana Cavey,Mark Woodhall,Siddharth Arora,T Winkler,Eric Schiffer,Angela Vincent,Gabriele C. DeLuca,Nicola R. Sibson,M. Isabel Leite,Patrick Waters,Daniel C. Anthony,Jacqueline Palace +17 more
TL;DR: Despite overlap in clinical measures in these three diseases, the distinct plasma metabolic patterns support their distinct serological profiles and confirm that these conditions are indeed different at a molecular level.
Journal ArticleDOI
Plasma Nuclear Magnetic Resonance Metabolomics Discriminates Between High and Low Endoscopic Activity and Predicts Progression in a Prospective Cohort of Patients With Ulcerative Colitis
Fay Probert,Alissa Walsh,Marta Jagielowicz,Tianrong Yeo,Claridge Tdw.,Alison Simmons,Simon Travis,Daniel C. Anthony +7 more
TL;DR: Plasma NMR metabolite analysis has the potential to provide a low-cost, minimally invasive technique that may be a surrogate for endoscopic assessment, with predictive capacity.
Journal ArticleDOI
Classifying the antibody-negative NMO syndromes: Clinical, imaging, and metabolomic modeling
Tianrong Yeo,Fay Probert,Maciej Juryńczyk,M Sealey,Ana Cavey,Claridge Tdw.,Mark Woodhall,Patrick Waters,Maria Isabel Leite,Daniel C. Anthony,Jacqueline Palace +10 more
TL;DR: PCA identifies 3 phenotypic subgroups within antibody-negative patients and that the metabolite discriminators of RRMS and Ab-NMOSD suggest that these groupings have some pathogenic meaning, may provide useful diagnostic clues when seeing antibody- negative patients in the clinic.
Journal ArticleDOI
Solution phase structures of enantiopure and racemic lithium N-benzyl-N-(α-methylbenzyl)amide in THF: low temperature 6Li and 15N NMR spectroscopic studies
Claridge Tdw.,Stephen G. Davies,Dennis Kruchinin,Barbara Odell,Paul M. Roberts,Angela J. Russell,James E. Thomson,Steven M. Toms +7 more
TL;DR: In this paper, the antipodes of lithium N -benzyl-N -(α-methyl benzyl)amide are highly efficient enantiopure ammonia equivalents for the asymmetric synthesis of β-amino acid derivatives via conjugate addition.