C
Clarissa A. Borges
Researcher at University of California, Berkeley
Publications - 9
Citations - 86
Clarissa A. Borges is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Trimethoprim & Drug resistance. The author has an hindex of 4, co-authored 9 publications receiving 44 citations.
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Journal ArticleDOI
Escherichia coli from Commercial Broiler and Backyard Chickens Share Sequence Types, Antimicrobial Resistance Profiles, and Resistance Genes with Human Extraintestinal Pathogenic Escherichia coli.
TL;DR: There is potential for transmission of E. coli and antimicrobial resistance genes from poultry to humans, perhaps through environmental contamination, direct contact, or consumption, and additional research is needed to understand the potential direction and pathways of transmission.
Journal ArticleDOI
A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo
Xiaojian Wang,Clarissa A. Borges,Xinghai Ning,Mohammad A. Rafi,Jingtuo Zhang,Bora Park,Kiyoko Takemiya,Carlo Lo Sterzo,W. Robert Taylor,W. Robert Taylor,W. Robert Taylor,Lee W. Riley,Niren Murthy +12 more
TL;DR: A trimethoprim conjugate of maltodextrin termed TM-TMP is presented, which increased the water solubility of trimethOPrim by over 100 times, was stable to serum enzymes, and was active against urinary tract infections in mice.
Journal ArticleDOI
A traceless linker for aliphatic amines that rapidly and quantitatively fragments after reduction.
Maomao He,Jie Li,Hesong Han,Clarissa A. Borges,Gabriel Neiman,Joachim Justad Røise,Piotr Hadaczek,Rima Mendonsa,Victoria R Holm,Ross C. Wilson,Krystof S. Bankiewicz,Yumiao Zhang,Yumiao Zhang,Corinne M. Sadlowski,Kevin E. Healy,Lee W. Riley,Niren Murthy +16 more
TL;DR: Dec was able to reversibly modify the lysine residues on CRISPR–Cas9 with either PEG, the cell penetrating peptide Arg10, or donor DNA, and generated Cas9 conjugates with significantly improved biological properties, making it a more suitable candidate for genome editing in animals.
Journal ArticleDOI
Monoclonal antibody-mediated detection of CTX-M β-lactamases in Gram-negative bacteria
Nicole J. Tarlton,Tiffany S. Satoorian,Anand Panchal,Clarissa A. Borges,Mark Geisberg,Lee W. Riley +5 more
TL;DR: A highly sensitive and specific sandwich ELISA, capable of detecting CTX-M enzyme production in GNB pathogens is developed.
Journal ArticleDOI
A Dual Enzyme-Based Biochemical Test Rapidly Detects Third-Generation Cephalosporin-Resistant CTX-M-Producing Uropathogens in Clinical Urine Samples.
Nicole J. Tarlton,Danka-Florence Petrovic,Bradley W. Frazee,Clarissa A. Borges,Emily M Pham,Aubrianne K. Milton,Nicole Jackson,Tara R. deBoer,Niren Murthy,Lee W. Riley +9 more
TL;DR: It is shown that a chromogenic, dual enzyme-mediated amplification system (termed DETECT [dual-enzyme trigger-enabled cascade technology]) can identify CTX-M-producing GNB from unprocessed urine samples in 30 minutes, which could improve initial antibiotic selection.