A metal-free, simple, and scalable method for the synthesis of the amides (III), (V), (VII), and (X) is developed from commercially available or easily synthesized starting materials.

Cross Coupling of Acyl and Aminyl Radicals: Direct Synthesis of Amides Catalyzed by Bu4NI with TBHP as an Oxidant

Chemical compositions and larvicidal activities of leaf essential oils from two eucalyptus species

Received 11 August 2009; returned 7 September 2009; revised 11 September 2009; accepted 12 September 2009 Objectives: Effective disinfection and antisepsis is pivotal in preventing infections within the healthcare setting. Chlorhexidine digluconate (CHG) is a widely used disinfectant/antiseptic possessing broad-spectrum antimicrobial activity; however, its penetration into bacterial biofilms and human skin is poor. The aim of this study was to investigate the antimicrobial efficacy of crude eucalyptus oil (EO) and its main component 1,8-cineole (a recognized permeation enhancer), alone and in combination with CHG, against a panel of clinically relevant microorganisms grown in planktonic and biofilm cultures. Methods: MICs and minimum bactericidal/fungicidal concentrations were determined for each microorganism grown in suspension and biofilm using microbroth dilution and ATP bioluminescence, respectively. Chequerboard assays were used to determine synergistic, indifferent or antagonistic interactions between CHG and EO or 1,8-cineole. Results: Antimicrobial activity was demonstrated by CHG, EO and 1,8-cineole; however, CHG was significantly more active against microorganisms in both planktonic and biofilm modes of growth (P<0.05). Crude EO was significantly more efficacious against microorganisms grown in suspension compared with 1,8-cineole (P<0.05). Synergistic activity was demonstrated between CHG and both EO and 1,8-cineole against suspensions of Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Escherichia coli and Candida albicans, and biofilm cultures of MRSA and Pseudomonas aeruginosa. Conclusions: In conclusion, CHG may be combined with either crude EO or its major component 1,8cineole for enhanced, synergistic antimicrobial activity against a wide range of microorganisms in planktonic and biofilm modes of growth; however, the superior antimicrobial efficacy associated with crude EO alone, compared with 1,8-cineole, favours its combination with CHG.

/pdf/antimicrobial-efficacy-of-eucalyptus-oil-and-1-8-cineole-4p78nwdpdg.pdf

Antimicrobial efficacy of eucalyptus oil and 1,8-cineole alone and in combination with chlorhexidine digluconate against microorganisms grown in planktonic and biofilm cultures.

Peel and leaf oils of 43 taxa of lemons and limes were obtained from fruits and leaves collected from trees submitted to the same pedoclimatic and cultural conditions. Their chemical composition was investigated by capillary GC, GC-MS, and (13)C NMR, and the results were submitted to principal component analysis to check for chemical variability. Three major chemotypes were distinguished for lemon peel oils: limonene; limonene/beta-pinene/gamma-terpinene; and limonene/linalyl acetate/linalool. Two chemotypes were identified for lemon leaf oils: limonene/beta-pinene/geranial/neral and linalool/linalyl acetate/alpha-terpineol. In lime peel oils, four chemotypes were distinguished: limonene; limonene/gamma-terpinene; limonene/beta-pinene/gamma-terpinene; and limonene/gamma-terpinene/beta-pinene/oxygenated products. Four others were identified for lime leaf oils: beta-pinene/limonene; limonene/geranial/neral; limonene/linalool/citronellal; and limonene/sabinene/citronellal/linalool. These results were interpreted using principal component analysis.

Volatile components of peel and leaf oils of lemon and lime species.

Osmitopsis asteriscoides (Asteraceae)-the antimicrobial activity and essential oil composition of a Cape-Dutch remedy.

Analysis of the variation of the essential oil composition of Eucalyptus globulus Labill. from Portugal using multivariate statistical analysis

Determinations cinetiques par microcalorimetrie differentielle en programmation de temperature. I. Considerations generales sur l'appareillage et les reactions de decomposition d'amorceurs radicalaires en solution

Studies on the chemical composition of the essential oil from leaves of selected Eucalyptus globulus Labill. ssp. globulus trees have been undertaken. The hydrodistilled samples were analysed by GLC and GC-MS. Fifty-three oil components have been identified; 1,8-cineole, α-pinene, limonene, aromadendrene, δ-cadinene, and globulol were the most abundant compounds, representing 93% of the total oil.

The essential oil of Eucalyptus globulus Labill. from Portugal

Delta-pyrone`ne : Epoxydation se´lective et acce`s aux cyclocitrals

Determinations cinetiques par microcalorimetrie differentielle en programmation de temperature. X. Decompositions simultanees spontanee et induite du peroxyde de benzoyle en solution

Claude Filliatre

Papers

Analysis of the variation of the essential oil composition of Eucalyptus globulus Labill. from Portugal using multivariate statistical analysis

Determinations cinetiques par microcalorimetrie differentielle en programmation de temperature. I. Considerations generales sur l'appareillage et les reactions de decomposition d'amorceurs radicalaires en solution

The essential oil of Eucalyptus globulus Labill. from Portugal

Delta-pyrone`ne : Epoxydation se´lective et acce`s aux cyclocitrals

Determinations cinetiques par microcalorimetrie differentielle en programmation de temperature. X. Decompositions simultanees spontanee et induite du peroxyde de benzoyle en solution