C
Claude Frehel
Researcher at French Institute of Health and Medical Research
Publications - 30
Citations - 1737
Claude Frehel is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Phagosome & Listeriolysin O. The author has an hindex of 21, co-authored 30 publications receiving 1672 citations.
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Journal ArticleDOI
Evidence for inhibition of fusion of lysosomal and prelysosomal compartments with phagosomes in macrophages infected with pathogenic Mycobacterium avium.
TL;DR: Two types of experiment suggest that viable M. avium can impair phagosome-pinosome fusions, suggesting that some of the live bacteria are resistant to the hydrolytic enzymes of the phagolysosomal environment.
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The role of the embA and embB gene products in the biosynthesis of the terminal hexaarabinofuranosyl motif of Mycobacterium smegmatis arabinogalactan.
Vincent Escuyer,Marie-Annick Lety,Jordi B. Torrelles,Kay-Hooi Khoo,Jyh-Bing Tang,Christopher D. Rithner,Claude Frehel,Michael R. McNeil,Patrick J. Brennan,Delphi Chatterjee +9 more
TL;DR: Results clearly show that both EmbA and EmbB proteins are involved in the formation of the proper terminal hexaarabinofuranoside motif in AG, thus paving the way for future studies to identify the complete array of arabinosyltransferases involved inThe synthesis of mycobacterial cell wall arabinan.
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Biogenesis of Leishmania-harbouring parasitophorous vacuoles following phagocytosis of the metacyclic promastigote or amastigote stages of the parasites.
Nathalie Courret,Claude Frehel,Nelly Gouhier,Marcel Pouchelet,Eric Prina,Pascal Roux,Jean-Claude Antoine +6 more
TL;DR: The kinetics of acquisition of the different late endosome/lysosome 'markers' by the phagosomes were similar to those measured after infection with metacyclics, which suggests that promastigote phagocytosis mainly occurs in a polarized manner, with the cell body entering the macrophages first.
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spoIIQ, a forespore‐expressed gene required for engulfment in Bacillus subtilis
TL;DR: A new locus is described, spoIIQ, which is transcribed in the forespore and which encodes a membrane‐bound protein required at a late stage of engulfment in Bacillus subtilis cells.
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Implication of phagosome-lysosome fusion in restriction of Mycobacterium avium growth in bone marrow macrophages from genetically resistant mice
TL;DR: It is shown that growth of this bacterium is restricted in marrow M phi s from resistant mice, and the mechanism by which the Bcg gene exerts control over the phagolysosomal fusion is discussed.