C
Claude Penit
Researcher at French Institute of Health and Medical Research
Publications - 25
Citations - 1367
Claude Penit is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: T cell & Thymocyte. The author has an hindex of 20, co-authored 25 publications receiving 1346 citations.
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Journal Article
Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice.
TL;DR: The kinetics and cell size evolution suggest that the majority of these cells do not give rise to CD4+CD8+ cells, and in RAG-2-/- cells, the block at the CD44-CD25high stage involved all cells.
Journal ArticleDOI
Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes
Armelle Le Campion,Christine Bourgeois,Florence Lambolez,Bruno Martin,Sandrine Léaument,Nicole Dautigny,Corinne Tanchot,Claude Penit,Bruno Lucas +8 more
TL;DR: It is demonstrated that the proliferation of the first thymic emigrants reaching the periphery requires T cell antigen receptor-self-peptide/self-MHC interactions and is regulated by the size of the peripheral T cell pool.
Journal Article
Production, selection, and maturation of thymocytes with high surface density of TCR.
TL;DR: The data suggest that high TCR expression and cell activation are necessary for positive selection and subsequent T cell maturation.
Journal Article
Sequential events in thymocyte differentiation and thymus regeneration revealed by a combination of bromodeoxyuridine DNA labeling and antimitotic drug treatment.
Claude Penit,F Vasseur +1 more
TL;DR: Results suggest that these L3T4+ SP cells are generated from DP cells in the absence of proliferation, indicating that they contain a resting subset and that they are renewed by emigration rather than by autonomous in situ proliferation.
Journal Article
T cell deletion induced by chronic infection with mouse mammary tumor virus spares a CD25-positive, IL-10-producing T cell population with infectious capacity.
Martine Papiernik,do Carmo Leite-de-MoraesM,Christiane Pontoux,A M Joret,Benedita Rocha,Claude Penit,Michel Dy +6 more
TL;DR: It is found that T cells recognizing viral superantigen (vSAG) can be subdivided into two distinct functional subsets based on IL-2R alpha (CD25) expression, which may play a role in the control of viral infection and tolerance induction via vSAG recognition and IL-10 production.