C
Claudia Lange
Researcher at University of Hamburg
Publications - 76
Citations - 4347
Claudia Lange is an academic researcher from University of Hamburg. The author has contributed to research in topics: Mesenchymal stem cell & Stem cell. The author has an hindex of 30, co-authored 75 publications receiving 4081 citations.
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Journal ArticleDOI
Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms.
TL;DR: It is concluded that the early, highly significant renoprotection obtained with MSC is of considerable therapeutic promise for the cell-based management of clinical ARF.
Journal ArticleDOI
Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats.
Claudia Lange,Florian Tögel,Harald Ittrich,Frederic Clayton,Claus Nolte-Ernsting,Axel R. Zander,Christof Westenfelder +6 more
TL;DR: It is shown in I/R-induced ARF in rats, modeling the most common form of clinical ARF, that infusion of mesenchymal stem cells enhances recovery of renal function and opens the possibility for a cell-based paradigm shift in the treatment of I-R ARF.
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Accelerated and safe expansion of human mesenchymal stromal cells in animal serum‐free medium for transplantation and regenerative medicine
Claudia Lange,Figen Cakiroglu,Andrej-Nikolai Spiess,Heike Cappallo-Obermann,Judith Dierlamm,Axel R. Zander +5 more
TL;DR: A GMP‐compatible protocol for safe and accelerated expansion of hMSC to be used in cell and tissue therapy and gene expression profiles show increased mRNA levels of genes involved in cell cycle and DNA replication and downregulation of developmental and differentiation genes, supporting the observation of increased MSC‐expansion in PL‐supplemented medium.
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Bystander killing of malignant glioma by bone marrow-derived tumor-infiltrating progenitor cells expressing a suicide gene
Hrvoje Miletic,Yvonne Fischer,Sara Litwak,Tsanan Giroglou,Yannic Waerzeggers,Alexandra Winkeler,Huongfeng Li,Uwe Himmelreich,Claudia Lange,Werner Stenzel,Martina Deckert,Harald Neumann,Andreas H. Jacobs,Dorothee von Laer +13 more
TL;DR: Bone marrow-derived, highly proliferative subpopulation of mesenchymal stem cells-here termed bone marrow- derived tumor-infiltrating cells (BM-TICs)-was genetically modified for the treatment of malignant glioma in a rat model and therefore hold great potential for the therapy ofmalignant brain tumors in humans.
Journal ArticleDOI
Evidence of peripheral blood-derived, plastic-adherent CD34(-/low) hematopoietic stem cell clones with mesenchymal stem cell characteristics.
TL;DR: Before autologous stem cell transplantation, one clone of choice was transfected with a retroviral construct containing the green‐fluorescence protein (GFP) and cells were immortalized using the SV‐40 large T antigen, and various fibroblast‐like clones were established.