Showing papers in "Kidney International in 2005"

TL;DR: A survey and conference was conducted and a controversies conference was sponsored to provide a clear understanding to both the nephrology and nonnephrology communities of the evidence base for the definition and classification recommended by Kidney Disease Quality Outcome Initiative (K/DOQI).

TL;DR: Uric acid was found to inhibit both basal and vascular endothelial growth factor (VEGF)-induced nitric oxide production in bovine aortic endothelial cells and may provide insight into a pathogenic mechanism by which uric acid may induce hypertension and vascular disease.

TL;DR: Given the strong association between proinflammatory cytokines and complications common in end-stage renal disease, such as vascular calcification and wasting, the potential role of both general and targeted anticytokine treatment strategies in ESRD patients needs further evaluation.

TL;DR: New hemodialysis patients with no evidence of coronary calcification showed little evidence of disease development over 18 months independent of phosphate binder therapy, however, subjects with evidence of at least mild coronary calcify had significant progression at 6, 12, and 18 months.

TL;DR: This study expands the understanding of the relationship between altered mineral metabolism and outcomes and identifies several potential opportunities for improved practice in this area.

TL;DR: Combining results from 4 clinical trials, randomization to cinacalcet led to significant reductions in the risk of parathyroidectomy, fracture, and cardiovascular hospitalization, along with improvements in self-reported physical function and diminished pain.

TL;DR: Many experimental studies provide evidence for a greater perturbation in renal functions by dimeric contrast media in comparison to nonionic monomers as the widely used nonionic low osmolar contrast media.

TL;DR: These studies provide a potential mechanism by which hyperuricemia can mediate hypertension and renal disease and partially prevented arteriolopathy and glomerular hypertension associated with significantly less infiltration of CD5+ cells.

TL;DR: DM is a risk factor for the development of kidney stones and additional studies are needed to determine if the increased risk of DM in stone formers is due to subclinical insulin resistance.

TL;DR: An increased emphasis should be placed on early initiation of CRRT and inotropic agent use over fluid administration to maintain acceptable blood pressure after initial resuscitative efforts, it is suggested.

TL;DR: Two mechanisms are discussed: (1) the loss of nephrons leads to compensatory mechanisms in the remaining nephons (glomerular hypertension, hyperfiltration, hypertrophy) which increase their vulnerability to any further challenge (overload hypothesis) and (2) a proteinuric glomerular disease leads to tubulointerstitial inflammation and fibrosis, accounting for the further deterioration of renal function (fibrosis hypothesis).

TL;DR: The role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease is discussed in this paper, where ACE inhibitors and AII receptor antagonists are used in combination to maximize RAAS inhibition and more effectively reduce proteinuria and GFR decline in diabetic and nondiabetic renal disease.

TL;DR: The acute renal impairment reflected the different prerenal and renal factors that exerted renal insult occurring in the context of multiorgan failure and carried a high mortality.

TL;DR: It is shown in I/R-induced ARF in rats, modeling the most common form of clinical ARF, that infusion of mesenchymal stem cells enhances recovery of renal function and opens the possibility for a cell-based paradigm shift in the treatment of I-R ARF.

TL;DR: The direct and indirect costs of nephrolithiaisis are substantial among working-age adults and interventions that prevent recurrence among known stone formers may be a cost-effective component of disease management programs.

TL;DR: The impact of chronic kidney disease on the global burden of diseases is probably underestimated by current methods of evaluation but complex interaction are clearly emerging between chronic kidney, cardiovascular disease, and diabetes.

TL;DR: The data show that renal SDF-1 is a currently unrecognized mediator of homing to and migration of CXCR4 expressing cells in the injured kidney, and suggest that S DF-1 may be a major signal involved in kidney repair.

TL;DR: Both high CRP and low albumin, measured in CKD stages 3 and 4, are independent risk factors for all-cause mortality, suggesting that highCRP and hypoalbuminemia provide prognostic information independent of each other in CKd.

TL;DR: It is demonstrated that fetuin-A, OPG, and MGP play an important role in the pathogenesis of uremic vascular calcification.

TL;DR: It is postulate that aggressive detection and treatment of post-transplant hyperglycemia may significantly reduce CV morbidity and mortality after kidney transplantation and is associated with increasing CV risk.

TL;DR: Reduction of proteinuria favored patients on paricalcitol, regardless of age, sex, race, diabetes mellitus, hypertension, or use of therapies to block the renin-angiotensin-aldosterone system (RAAS).

TL;DR: It is suggested that chronic kidney disease is an independent risk factor for the occurrence of cardiovascular disease in the general Japanese population.

TL;DR: The data demonstrate that both EPA and DHA down-regulate LPS-induced activation of NF-kappaB via a PPAR-gamma-dependent pathway in HK-2 cells, and suggest that PPAR -gamma activation by EPA andDHA may be one of the underlying mechanisms for the beneficial effects of fish oil.

TL;DR: A low fetuin-A level is associated with malnutrition, inflammation, and atherosclerosis (carotid plaques), as well as with increased cardiovascular and all-cause mortality, and this indicates that ESRD patients with the AHSG 256Ser allele are at risk of accelerated vascular calcification.

TL;DR: Perinatal programming of these 2 diseases, as well as of nephron number, may have a synergistic impact on the development of hypertension and kidney disease in later life.

TL;DR: Pravastatin appears to prevent loss of kidney function to a greater extent in individuals with greater evidence of inflammation, although this was of borderline significance, and data suggest that inflammation may mediate the loss of kidneys function among subjects with chronic kidney disease and concomitant coronary disease.

TL;DR: In subjects on dialysis with secondary HPT, cinacalcet facilitates achievement of the K/DOQI-recommended targets for PTH, calcium, phosphorus, and Ca x P.

TL;DR: Among a nationally representative sample of adults, reduced glomerular filtration rate was associated with a higher prevalence of hypothyroidism, with many subclinical cases.

TL;DR: The aim of this review is to summarize the current understanding of the pathogenesis of preeclampsia with special emphasis on the recent discovery that circulating anti-angiogenic proteins of placental origin may play an important role in the pathogenic of proteinuria and hypertension of preeClampsia.

TL;DR: Improvements in and reimbursement for pre-ESRD education could provide an equal and timely access for all medically suitable patients to various RRTs.