Claudia Lennicke

TL;DR: This article reviews the current knowledge about the intracellular production of H2O2 along with redox signaling pathways mediating either the growth or apoptosis of tumor cells and how the targeting of H 2O2-linked sources and/or signaling components involved in tumor progression and survival might lead to novel therapeutic targets.

TL;DR: This review will focus on the methods and technologies, which are currently applied for the detection, identification, and quantification of oxPTMs including the design of high throughput approaches and the analyses ofOxPTMs related to physiological and pathological conditions.

TL;DR: Comparisons of effects of feeding distinct Se compounds and concentrations on hepatic metabolism and expression profiles of mice indicate that compound-specific effects of high doses appear to be independent of selenoproteins.

TL;DR: MSA might affect the malignant phenotype of various tumor cells by restoring MHC class I APM component expression due to an altered redox status and by partially mimicking IFN-gamma signaling thereby providing a novel mechanism for the chemotherapeutic potential of methylselenol generating Se compounds.

TL;DR: The observed expression pattern suggests that GPx2 KO goblet cells might be limited in synthesizing CLCA1, which seems to be important for the modulation of cell fate decisions in the murine intestinal epithelium.