B
Barbara Seliger
Researcher at Martin Luther University of Halle-Wittenberg
Publications - 258
Citations - 9543
Barbara Seliger is an academic researcher from Martin Luther University of Halle-Wittenberg. The author has contributed to research in topics: Immune system & Human leukocyte antigen. The author has an hindex of 45, co-authored 222 publications receiving 7324 citations. Previous affiliations of Barbara Seliger include Wittenberg University & Fraunhofer Society.
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Journal ArticleDOI
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Almut Brand,Katrin Singer,Gudrun E. Koehl,Marlene Kolitzus,Gabriele Schoenhammer,Annette Thiel,Carina Matos,Christina Bruss,Sebastian Klobuch,K. Peter,K. Peter,Michael Kastenberger,Christian Bogdan,Ulrike Schleicher,Andreas Mackensen,Evelyn Ullrich,Stefan Fichtner-Feigl,Stefan Fichtner-Feigl,Rebecca Kesselring,Matthias Mack,Matthias Mack,Uwe Ritter,Maximilian Schmid,Maximilian Schmid,Christian U. Blank,Katja Dettmer,Peter J. Oefner,Petra Hoffmann,Petra Hoffmann,Stefan Walenta,E. K. Geissler,Jacques Pouysségur,Andreas Villunger,André Steven,Barbara Seliger,Stephan Schreml,Sebastian Haferkamp,Elisabeth Kohl,Sigrid Karrer,Mark Berneburg,Wolfgang Herr,Wolfgang Mueller-Klieser,Kathrin Renner,Kathrin Renner,Marina Kreutz,Marina Kreutz +45 more
TL;DR: It is shown that LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and NK cells, and is a potent inhibitor of function and survival of T andNK cells leading to tumor immune escape.
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Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape.
Leisha A. Emens,Paolo A. Ascierto,Phillip K. Darcy,Sandra Demaria,Alexander M.M. Eggermont,William L. Redmond,Barbara Seliger,Francesco M. Marincola +7 more
TL;DR: Cancer immunotherapy is now established as a powerful way to treat cancer and the recent clinical success of immune checkpoint blockade highlights both the universal power of treating the immune system across tumour types and the unique features of cancer immunotherapy.
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Classification of current anticancer immunotherapies
Lorenzo Galluzzi,Erika Vacchelli,José Manuel Bravo-San Pedro,Aitziber Buqué,Laura Senovilla,Elisa E. Baracco,Norma Bloy,Francesca Castoldi,Jean Pierre Abastado,Patrizia Agostinis,Ron N. Apte,Fernando Aranda,Maha Ayyoub,Philipp Beckhove,Jean-Yves Blay,Laura Bracci,Anne Caignard,Chiara Castelli,Federica Cavallo,Estaban Celis,Vincenzo Cerundolo,Aled Clayton,Mario P. Colombo,Lisa M. Coussens,Madhav V. Dhodapkar,Alexander M.M. Eggermont,Douglas T. Fearon,Wolf H. Fridman,Jitka Fucikova,Dmitry I. Gabrilovich,Jérôme Galon,Abhishek D. Garg,François Ghiringhelli,François Ghiringhelli,Giuseppe Giaccone,Giuseppe Giaccone,Eli Gilboa,Sacha Gnjatic,Axel Hoos,Anne Hosmalin,Anne Hosmalin,Anne Hosmalin,Dirk Jäger,Pawel Kalinski,Klas Kärre,Oliver Kepp,Rolf Kiessling,John M. Kirkwood,Eva Klein,Alexander Knuth,Claire E. Lewis,Roland S. Liblau,Roland S. Liblau,Roland S. Liblau,Michael T. Lotze,Enrico Lugli,Jean-Pierre Mach,Fabrizio Mattei,Domenico Mavilio,Ignacio Melero,Cornelis J. M. Melief,E. A. Mittendorf,Lorenzo Moretta,Adekunke Odunsi,Hideho Okada,Anna Karolina Palucka,Marcus E. Peter,Kenneth J. Pienta,Angel Porgador,George C. Prendergast,George C. Prendergast,Gabriel A. Rabinovich,Nicholas P. Restifo,Naiyer A. Rizvi,Catherine Sautès-Fridman,Hans Schreiber,Barbara Seliger,Hiroshi Shiku,Bruno Silva-Santos,Mark J. Smyth,Mark J. Smyth,Daniel E. Speiser,Daniel E. Speiser,Radek Spisek,Pramod K. Srivastava,James E. Talmadge,Eric Tartour,Sjoerd H. van der Burg,Benoît Van den Eynde,Benoît Van den Eynde,Richard G. Vile,Hermann Wagner,Jeffrey S. Weber,Theresa L. Whiteside,Jedd D. Wolchok,Jedd D. Wolchok,Laurence Zitvogel,Weiping Zou,Guido Kroemer +98 more
TL;DR: A critical, integrated classification of anticancer immunotherapies is proposed and the clinical relevance of these approaches is discussed.
Journal ArticleDOI
Hydrogen peroxide – production, fate and role in redox signaling of tumor cells
TL;DR: This article reviews the current knowledge about the intracellular production of H2O2 along with redox signaling pathways mediating either the growth or apoptosis of tumor cells and how the targeting of H 2O2-linked sources and/or signaling components involved in tumor progression and survival might lead to novel therapeutic targets.
Journal Article
Dengue Virus Infection of Human Endothelial Cells Leads to Chemokine Production, Complement Activation, and Apoptosis
TL;DR: It is shown that infection of human endothelial cells with DV induces the transcriptional up-regulation and secretion of RANTES and IL-8 and, in the presence of anti-dengue Abs, the formation of nonlytic complement complexes.