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Claudia Piutti
Researcher at Pharmacia
Publications - 19
Citations - 897
Claudia Piutti is an academic researcher from Pharmacia. The author has contributed to research in topics: Kinase activity & Total synthesis. The author has an hindex of 11, co-authored 17 publications receiving 819 citations.
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Journal ArticleDOI
A Submarine Journey: The Pyrrole-Imidazole Alkaloids
Barbara Forte,Beatrice Malgesini,Claudia Piutti,Francesca Quartieri,Alessandra Scolaro,Gianluca Papeo +5 more
TL;DR: This review will account for the progress in achieving the total synthesis of the more biologically enticing members of this class of natural products.
Journal ArticleDOI
3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 1. Lead Finding
Paolo Pevarello,Maria Gabriella Brasca,Raffaella Amici,Paolo Orsini,Gabriella Traquandi,Luca Corti,Claudia Piutti,Pietro Sansonna,Manuela Villa,Pierce Betsy S,Maurizio Pulici,Patrizia Giordano,Katia Martina,Edward L. Fritzen,Richard Allen Nugent,Elena Casale,Alexander D. Cameron,Marina Ciomei,Fulvia Roletto,Antonella Isacchi,Gianpaolo Fogliatto,Enrico Pesenti,Wilma Pastori,Aurelio Marsiglio,Karen L. Leach,Paula M. Clare,Francesco Fiorentini,Mario Varasi,and Anna Vulpetti,Martha A. Warpehoski +29 more
TL;DR: From a high-throughput screening effort, a new class of CDK2/cyclin A/E inhibitors is identified and the hit-to-lead expansion of this class is described.
Journal ArticleDOI
Total Synthesis of the Amaryllidaceae Alkaloid (+)‐Plicamine and Its Unnatural Enantiomer by Using Solid‐Supported Reagents and Scavengers in a Multistep Sequence of Reactions
Journal ArticleDOI
The Piancatelli rearrangement: new applications for an intriguing reaction.
TL;DR: A re-emergence of this reaction has been seen recently, including developments of the Piancatelli rearrangement with some interesting inter- and intramolecular variants.
Journal ArticleDOI
3-Aminopyrazole Inhibitors of Cdk2-Cyclin a as Antitumor Agents. 2. Lead Optimization
Paolo Pevarello,Maria Gabriella Brasca,Paolo Orsini,Gabriella Traquandi,Antonio Longo,Marcella Nesi,Fabrizio Orzi,Claudia Piutti,Pietro Sansonna,Mario Varasi,Alexander D. Cameron,Anna Vulpetti,Fulvia Roletto,Rachele Alzani,Marina Ciomei,Clara Albanese,Wilma Pastori,Aurelio Marsiglio,Enrico Pesenti,Francesco Fiorentini,Jim R. Bischoff,Ciro Mercurio +21 more
TL;DR: Compound 13 was more active than PNU-292137 in vivo in the A2780 xenograft model showing a tumor growth inhibition of 70%.