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Gianpaolo Fogliatto
Researcher at Pharmacia
Publications - 16
Citations - 1271
Gianpaolo Fogliatto is an academic researcher from Pharmacia. The author has contributed to research in topics: Fragment-based lead discovery & Heat shock protein. The author has an hindex of 12, co-authored 16 publications receiving 1171 citations. Previous affiliations of Gianpaolo Fogliatto include Pfizer & University of Milan.
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Journal ArticleDOI
WaterLOGSY as a method for primary NMR screening: practical aspects and range of applicability.
TL;DR: The high sensitivity of the technique in combination with the easy deconvolution of the mixtures for the identification of the active components, significantly reduces the amount of material and time needed for the NMR screening process.
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3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 1. Lead Finding
Paolo Pevarello,Maria Gabriella Brasca,Raffaella Amici,Paolo Orsini,Gabriella Traquandi,Luca Corti,Claudia Piutti,Pietro Sansonna,Manuela Villa,Pierce Betsy S,Maurizio Pulici,Patrizia Giordano,Katia Martina,Edward L. Fritzen,Richard Allen Nugent,Elena Casale,Alexander D. Cameron,Marina Ciomei,Fulvia Roletto,Antonella Isacchi,Gianpaolo Fogliatto,Enrico Pesenti,Wilma Pastori,Aurelio Marsiglio,Karen L. Leach,Paula M. Clare,Francesco Fiorentini,Mario Varasi,and Anna Vulpetti,Martha A. Warpehoski +29 more
TL;DR: From a high-throughput screening effort, a new class of CDK2/cyclin A/E inhibitors is identified and the hit-to-lead expansion of this class is described.
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Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors.
R.T. Bossi,M.B. Saccardo,Elena Ardini,Maria Menichincheri,Luisa Rusconi,Paola Magnaghi,Paolo Orsini,N. Avanzi,A.L. Borgia,M. Nesi,T. Bandiera,Gianpaolo Fogliatto,J.A. Bertrand +12 more
TL;DR: Analysis of the crystal structures of the unphosphorylated human ALK kinase domain in complex with the ATP competitive ligands PHA-E429 and NVP-TAE684 provides valuable information concerning the specific characteristics of the ALK active site as well as giving indications about how to obtain selective ALK inhibitors.
Journal ArticleDOI
A general NMR method for rapid, efficient, and reliable biochemical screening.
Claudio Dalvit,Elena Ardini,Maria Flocco,Gianpaolo Fogliatto,Nicola Mongelli,Marina Veronesi +5 more
TL;DR: A novel and sensitive NMR method for rapid, efficient, and reliable biochemical screening is presented and an interesting application of 3-FABS to functional genomics is also presented.
Journal ArticleDOI
Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma
Serena Pellegatta,Lorella Valletta,Cristina Corbetta,Monica Patanè,Ileana Zucca,Federico Riccardi Sirtori,Maria Grazia Bruzzone,Gianpaolo Fogliatto,Antonella Isacchi,Bianca Pollo,Gaetano Finocchiaro +10 more
TL;DR: The results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations and led to intratumoral up-regulation of IFN-γ, granzyme-b and perforin-1 and down- regulation of TGF-β2 and IL-10.