Clifford T. Ó’Ciardhá

TL;DR: In this article, the estimation of the secondary nucleation kinetics of paracetamol in ethanol solutions for cooling crystallization processes, by means of isothermal under-seeded batch experiments, is presented.

TL;DR: In this article, a study of the nucleation kinetics for cooling crystallisation of paracetamol-ethanol solutions in a batch reactor is described, where induction time experiments were conducted in order to estimate the nucleations of the system.

TL;DR: In this article, the growth kinetics of paracetamol crystals were evaluated in isolation, with the growth rate assumed to be size independent and prior knowledge of the MSZW was required, so that supersaturation ratios of 1.7-1.1 could be induced in solution without the occurrence of nucleation.

TL;DR: In this article, the primary nucleation kinetics were estimated for the anti-solvent crystallisation of paracetamol in methanol-water solutions from metastable zone widths and induction times at 25°C.

TL;DR: In this paper, a population balance incorporating nucleation, growth, and agglomeration, solved using quadrature method of moments, was coupled with a parameter estimation procedure, the seeded antisolvent crystallization of paracetamol from methanol and water was chosen as the model system.