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Cody A. Desjardins
Researcher at Boston University
Publications - 13
Citations - 540
Cody A. Desjardins is an academic researcher from Boston University. The author has contributed to research in topics: Dopaminergic & Regulation of gene expression. The author has an hindex of 11, co-authored 12 publications receiving 435 citations. Previous affiliations of Cody A. Desjardins include Harvard University.
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Journal ArticleDOI
Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration
Xiqun Chen,Thomas C. Burdett,Cody A. Desjardins,Robert Logan,Sara Cipriani,Yuehang Xu,Michael A. Schwarzschild +6 more
TL;DR: A neuroprotective role of endogenous urate in dopaminergic neurons is supported and the rationale for developing urate-elevating strategies as potential disease-modifying therapy for Parkinson’s disease is strengthened.
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MEF2 Transcription Factors Regulate Distinct Gene Programs in Mammalian Skeletal Muscle Differentiation
Nelsa L. Estrella,Cody A. Desjardins,Sarah E. Nocco,Amanda L. Clark,Yevgeniy Maksimenko,Francisco J. Naya +5 more
TL;DR: The results suggest that individual MEF2 family members are able to recognize specific targets among the entire cohort ofMEF2-regulated genes in the muscle genome, and provide opportunities to modulate the activity of MEf2 isoforms and their respective gene programs in skeletal muscle homeostasis and disease.
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The Function of the MEF2 Family of Transcription Factors in Cardiac Development, Cardiogenomics, and Direct Reprogramming.
TL;DR: A thorough understanding of the regulatory functions of the MEF2 family in cardiac development and cardiogenomics is required in order to develop effective therapeutic strategies to repair the diseased heart.
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Urate and Its Transgenic Depletion Modulate Neuronal Vulnerability in a Cellular Model of Parkinson's Disease
Sara Cipriani,Cody A. Desjardins,Thomas C. Burdett,Yuehang Xu,Kui Xu,Michael A. Schwarzschild +5 more
TL;DR: The findings correlate intracellular urate content in dopaminergic neurons with their toxin resistance in a cellular model of PD and suggest a facilitative role for astrocytes in the neuroprotective effect of urate.
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Postmortem brain levels of urate and precursors in Parkinson's disease and related disorders.
Nikolaus R. McFarland,Thomas C. Burdett,Cody A. Desjardins,Matthew P. Frosch,Michael A. Schwarzschild +4 more
TL;DR: Though limited in sample size, these findings lend support to the inverse association between urate levels and PD, as well as possibly AD, and the finding of increased urate in DLB brain tissue is novel and warrants further study.