C
Colin Clarke
Researcher at National Institutes of Health
Publications - 6
Citations - 533
Colin Clarke is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Macrophage migration inhibitory factor & Oxidative stress. The author has an hindex of 5, co-authored 6 publications receiving 408 citations.
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Journal ArticleDOI
Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease.
Coen Wiegman,Charalambos Michaeloudes,Gulammehdi Haji,Priyanka Narang,Colin Clarke,Kirsty E. Russell,Wuping Bao,Stelios Pavlidis,Peter J. Barnes,Justin Kanerva,Anton Bittner,Navin Rao,Michael P. Murphy,Paul Kirkham,Kian Fan Chung,Ian M. Adcock,Christopher E. Brightling,Donna E. Davies,Donna K. Finch,Andrew J. Fisher,Alasdair Gaw,Alan J. Knox,Ruth J. Mayer,Michael I. Polkey,Michael Salmon,David Singh +25 more
TL;DR: Mitochondrial dysfunction in patients with COPD is associated with excessive mitochondrial ROS levels, which contribute to enhanced inflammation and cell hyperproliferation.
Journal ArticleDOI
A comprehensive analysis of oxidative stress in the ozone-induced lung inflammation mouse model
Coen Wiegman,Feng Li,Colin Clarke,Elen Jazrawi,Paul Kirkham,Peter J. Barnes,Ian M. Adcock,Kian Fan Chung +7 more
TL;DR: In this article, the authors investigated the acute and chronic effects of ozone exposure-induced oxidative stress-related inflammation mechanics in mouse lung and found that ozone exposure was associated with increased levels of chemokines and cytokines in all ozone-exposed groups, indicating the presence of a persistent inflammatory environment in the lung.
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Bromodomain and Extraterminal Proteins Suppress NF-E2–Related Factor 2–Mediated Antioxidant Gene Expression
Charalambos Michaeloudes,Nicolas Mercado,Colin Clarke,Pankaj K. Bhavsar,Ian M. Adcock,Peter J. Barnes,Kian Fan Chung +6 more
TL;DR: BET proteins, particularly Brd2 and Brd4, may play a key role in the regulation of Nrf2-dependent antioxidant gene transcription and are hence an important target for augmenting antioxidant responses in oxidative stress–mediated diseases.
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Effects of N-acetylcysteine in ozone-induced chronic obstructive pulmonary disease model.
Feng Li,Feng Li,Cornelis Wiegman,Joanna Seiffert,Jie Zhu,Colin Clarke,Yan Chang,Pank Bhavsar,Ian M. Adcock,Junfeng Zhang,Xin Zhou,Kian Fan Chung +11 more
TL;DR: Emphysema and lung function changes were irreversible up to 6W after cessation of ozone exposure, and were not reversed by NAC, suggesting the beneficial effects of therapeutic NAC may be restricted to the ASM.
Journal ArticleDOI
The MIF antagonist ISO-1 attenuates corticosteroid-insensitive inflammation and airways hyperresponsiveness in an ozone-induced model of COPD
Kirsty E. Russell,Kian Fan Chung,Colin Clarke,Andrew L. Durham,Patrick Mallia,Joseph Footitt,Sebastian L. Johnston,Peter J. Barnes,Simon Hall,Karen D. Simpson,Malcolm R. Starkey,Philip M. Hansbro,Ian M. Adcock,Coen Wiegman +13 more
TL;DR: Levels in sputum and BAL macrophages from COPD patients were higher than those from non-smokers, with healthy smokers having intermediate levels and inhibition of MIF function blocks corticosteroid-insensitive lung inflammation and AHR.