D
David Singh
Researcher at University of Manchester
Publications - 7
Citations - 399
David Singh is an academic researcher from University of Manchester. The author has contributed to research in topics: Aclidinium bromide & Oxidative stress. The author has an hindex of 4, co-authored 7 publications receiving 292 citations.
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Journal ArticleDOI
Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease.
Coen Wiegman,Charalambos Michaeloudes,Gulammehdi Haji,Priyanka Narang,Colin Clarke,Kirsty E. Russell,Wuping Bao,Stelios Pavlidis,Peter J. Barnes,Justin Kanerva,Anton Bittner,Navin Rao,Michael P. Murphy,Paul Kirkham,Kian Fan Chung,Ian M. Adcock,Christopher E. Brightling,Donna E. Davies,Donna K. Finch,Andrew J. Fisher,Alasdair Gaw,Alan J. Knox,Ruth J. Mayer,Michael I. Polkey,Michael Salmon,David Singh +25 more
TL;DR: Mitochondrial dysfunction in patients with COPD is associated with excessive mitochondrial ROS levels, which contribute to enhanced inflammation and cell hyperproliferation.
Journal ArticleDOI
Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages
Martin A. Bewley,Julie A. Preston,Mohammed Mohasin,Helen M. Marriott,Richard C. Budd,Julie Swales,Paul Collini,David R. Greaves,Ruth W. Craig,Christopher E. Brightling,Louise E. Donnelly,Peter J. Barnes,David Singh,Steven D. Shapiro,Moira K. B. Whyte,David H. Dockrell +15 more
TL;DR: Up‐regulation of Mcl‐1 and chronic adaption to oxidative stress alter mitochondrial metabolism and microbicidal function, reducing the delayed phase of intracellular bacterial clearance in COPD.
Journal Article
Patient assessments of ease of use of Genuair® versus Aerolizer® and HandiHaler®
Rainard Fuhr,Helgo Magnussen,David Singh,Gonzalo de Miquel,Cynthia Caracta,Esther Garcia Gil +5 more
TL;DR: Patient assessments of convenience were higher for the Genuair® inhaler versus the Aerolizer® or HandiHaler®.
Journal ArticleDOI
Aclidinium Bromide in Patients With Chronic Obstructive Pulmonary Disease: Improvement in Symptoms and Health Status in the ATTAIN Stud
Paul W. Jones,Alvar Agusti,Eric D. Bateman,David Singh,Rosa Lamarca,Gonzalo de Miquel,Cynthia Caracta,Esther Garcia Gil +7 more
Journal ArticleDOI
Reduction of Exhaled Nitric Oxide by the DP2 antagonist GB001 in Patients with Mild Atopic Asthma.
TL;DR: Results suggest that GB001 reduces airway inflammation (FeNO) measured by day 28, and further studies are needed to confirm these findings.