Colvin Om

TL;DR: With HT, the DOX concentrations and fluorescence were tightly correlated with tumor growth delay, indicating that adequate (increased) drug delivery can be predictive of therapeutic effect and demonstrates the importance of rapid drug release from the drug carriers at the tumor site.

TL;DR: Temodal has activity against newly diagnosed GBM and AA and warrants continued evaluation of this agent, and pretherapy analysis of tumor DNA mismatch repair and, particularly, AGT protein expression may identify patients in whom tumors are resistant to Temodal.

TL;DR: The results extend the previous studies demonstrating the antitumor activity of nitrogen and phosphoramide mustard-based bifunctional alkylating agents in the treatment of human medulloblastoma continuous cell lines and transplantable xenografts, and support the continued use of these agents in clinical trials.

TL;DR: The results suggest that 4-HC resistance in medulloblastoma can be multifactorial and multiple distinct mechanisms of resistance were demonstrated.

TL;DR: While the enthalpies of 1,2 and 1,3 mustard cross-linked DNA were found to be very close, a 1, 3 structure was more flexible and may therefore be in a considerably higher entropic state.