C
Connie L. Erickson-Miller
Researcher at Kettering University
Publications - 4
Citations - 256
Connie L. Erickson-Miller is an academic researcher from Kettering University. The author has contributed to research in topics: In vivo & Myeloid. The author has an hindex of 3, co-authored 4 publications receiving 255 citations.
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Journal ArticleDOI
Differential toxicity of camptothecin, topotecan and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU-GM) in vitro
Connie L. Erickson-Miller,Richard D. May,Joseph E. Tomaszewski,Blaire Osborn,Martin J. Murphy,John G. Page,Ralph E. Parchment +6 more
TL;DR: The greater susceptibility of humans and dogs to the myelotoxicity of camptothecins, compared to mice, was evident in vitro at the cellular level, explaining why the curative doses of TPT and 9AC in mice with human tumor xenografts are not achievable in patients.
Journal ArticleDOI
Roles for In Vitro Myelotoxicity Tests in Preclinical Drug Development and Clinical Trial Planning
TL;DR: In clinical trial planning, in vitro colony-forming assays can be used to elucidate schedule dependency of myelotoxicity, to plan cytokine support, and to estimate dose-escalation effects.
Journal ArticleDOI
In Vivo-In Vitro Correlation of Myelotoxicity of 9-Methoxypyrazoloacridine [NSC-366140, PD115934] to Myeloid and Erythroid Hematopoietic Progenitors From Human, Murine, and Canine Marrow
Ralph E. Parchment,Donna A. Volpe,Patricia LoRusso,Connie L. Erickson-Miller,Martin J. Murphy,Charles K. Grieshaber +5 more
TL;DR: In vitro clonogenic assays of hematopoietic progenitors of myelotoxic agents can provide data that make both preclinical toxicology testing and clinical trial planning and interpretation more efficient and accurate, and quantitatively predict the AUCs at maximum tolerated dose in preclinical models and human patients.
Journal ArticleDOI
Effects of recombinant cytokines on murine megakaryocyte colony formation in a serum-free fibrin clot culture system.
Kiyoyuki Ogata,Connie L. Erickson-Miller,Takeo Nomura,Kazuhiro Abe,Zhang Zhao-Geng,Martin J. Murphy +5 more
TL;DR: A convenient serum-free fibrin clot culture system for murine megakaryocyte progenitor cells was developed and the culture and counting of colonies is much easier in this system, when compared with previously reported serum- free culture methods.