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Patricia LoRusso
Researcher at Yale Cancer Center
Publications - 634
Citations - 30456
Patricia LoRusso is an academic researcher from Yale Cancer Center. The author has contributed to research in topics: Cancer & Pharmacokinetics. The author has an hindex of 73, co-authored 589 publications receiving 26169 citations. Previous affiliations of Patricia LoRusso include Harvard University & Yale University.
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Journal ArticleDOI
Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study.
Nicole M. Kuderer,Toni K. Choueiri,Dimpy P. Shah,Yu Shyr,Samuel M. Rubinstein,Donna R. Rivera,Sanjay Shete,Chih-Yuan Hsu,Aakash Desai,Gilberto Lopes,Petros Grivas,Petros Grivas,Corrie A. Painter,Solange Peters,Michael A. Thompson,Ziad Bakouny,Gerald Batist,Tanios Bekaii-Saab,Mehmet Asim Bilen,Nathaniel Bouganim,Mateo Bover Larroya,Daniel Castellano,Salvatore Del Prete,Deborah B. Doroshow,Pamela C Egan,Arielle Elkrief,Dimitrios Farmakiotis,Daniel Blake Flora,Matthew D. Galsky,Michael Glover,Elizabeth A. Griffiths,Anthony P. Gulati,Shilpa Gupta,Navid Hafez,Thorvardur R. Halfdanarson,Jessica Hawley,Emily Hsu,Anup Kasi,Ali Raza Khaki,Ali Raza Khaki,Christopher Lemmon,Colleen Lewis,Barbara Logan,Tyler Masters,Rana R. McKay,Ruben A. Mesa,Alicia K. Morgans,Mary F. Mulcahy,Orestis A. Panagiotou,Prakash Peddi,Nathan A. Pennell,Kerry L. Reynolds,Lane R. Rosen,Rachel P. Rosovsky,Mary Salazar,Andrew Schmidt,Sumit A. Shah,Justin Shaya,John A. Steinharter,Keith Stockerl-Goldstein,Suki Subbiah,Donald C. Vinh,Firas Wehbe,Lisa Weissmann,Julie Tsu Yu Wu,Elizabeth Marie Wulff-Burchfield,Zhuoer Xie,Albert C. Yeh,Albert C. Yeh,Peter Paul Yu,Alice Zhou,Leyre Zubiri,Sanjay Mishra,Gary H. Lyman,Gary H. Lyman,Brian I. Rini,Jeremy L. Warner,Maheen Z. Abidi,Jared D. Acoba,Neeraj Agarwal,Syed A. Ahmad,Archana Ajmera,Jessica K. Altman,Anne H. Angevine,Nilo Azad,Michael H. Bar,Aditya Bardia,Jill S. Barnholtz-Sloan,Briana Barrow,Babar Bashir,Rimma Belenkaya,Stephanie Berg,Eric H. Bernicker,Christine Bestvina,Rohit Bishnoi,Genevieve M. Boland,Mark Bonnen,Gabrielle Bouchard,Daniel W. Bowles,Fiona Busser,Angelo Cabal,Paolo Caimi,Theresa M. Carducci,Carla Casulo,James L. Chen,Jessica M. Clement,David D. Chism,Erin Cook,Catherine Curran,Ahmad Daher,Mark E. Dailey,Saurabh Dahiya,John F. Deeken,George D. Demetri,Sandy DiLullo,Narjust Duma,Rawad Elias,Bryan A. Faller,Leslie A. Fecher,Lawrence E. Feldman,Christopher R. Friese,Paul Fu,Julie Fu,Andy Futreal,Justin F. Gainor,Jorge A. Garcia,David Gill,Erin A. Gillaspie,Antonio Giordano,Grace Glace,Axel Grothey,Shuchi Gulati,Michael J. Gurley,Balazs Halmos,Roy S. Herbst,Dawn L. Hershman,Kent Hoskins,Rohit Jain,Salma K. Jabbour,Alokkumar Jha,Douglas B. Johnson,Monika Joshi,Kaitlin M. Kelleher,Jordan Kharofa,Hina Khan,Jeanna Knoble,Vadim S. Koshkin,Amit Kulkarni,Philip E. Lammers,John C. Leighton,Mark A. Lewis,X. Li,Ang Li,K. M.Steve Lo,Arturo Loaiza-Bonilla,Patricia LoRusso,Clarke A. Low,Maryam B. Lustberg,Daruka Mahadevan,Abdul Hai Mansoor,Michelle Marcum,Merry Jennifer Markham,Catherine Handy Marshall,Sandeep H. Mashru,Sara Matar,Christopher McNair,Shannon K. McWeeney,Janice M. Mehnert,Alvaro G. Menendez,Harry Menon,Marcus Messmer,Ryan Monahan,Sarah Mushtaq,Gayathri Nagaraj,Sarah Nagle,Jarushka Naidoo,John M. Nakayama,Vikram M. Narayan,Heather H. Nelson,Eneida R. Nemecek,Ryan Nguyen,Pier Vitale Nuzzo,Paul E. Oberstein,Adam J. Olszewski,Susie Owenby,Mary M. Pasquinelli,John Philip,Sabitha Prabhakaran,Matthew Puc,Amelie G. Ramirez,Joerg Rathmann,Sanjay G. Revankar,Young Soo Rho,Terence Duane Rhodes,Robert L. Rice,Gregory J. Riely,Jonathan Riess,Cameron Rink,Elizabeth Robilotti,Lori J. Rosenstein,Bertrand Routy,Marc A. Rovito,M. Wasif Saif,Amit Sanyal,Lidia Schapira,Candice Schwartz,Oscar K. Serrano,Mansi R. Shah,Chintan Shah,Grace Shaw,Ardaman Shergill,Geoffrey Shouse,Heloisa P. Soares,Carmen C. Solorzano,Pramod K. Srivastava,Karen Stauffer,Daniel G. Stover,Jamie Stratton,Catherine Stratton,Vivek Subbiah,Rulla M. Tamimi,Nizar M. Tannir,Umit Topaloglu,Eli Van Allen,Susan Van Loon,Karen Vega-Luna,Neeta K. Venepalli,Amit Verma,Praveen Vikas,Sarah Wall,Paul L. Weinstein,Matthias Weiss,Trisha Wise-Draper,William A. Wood,Wenxin Xu,Susan Yackzan,Rosemary Zacks,Tian Zhang,Andrea J. Zimmer,Jack West +239 more
TL;DR: The outcomes of a cohort of patients with cancer and COVID-19 are characterised and potential prognostic factors for mortality and severe illness are identified and race and ethnicity, obesity status, cancer type, type of anticancer therapy, and recent surgery were not associated with mortality.
Journal ArticleDOI
Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study.
D. Ross Camidge,Yung-Jue Bang,Eunice L. Kwak,A. John Iafrate,Marileila Varella-Garcia,Stephen B. Fox,Gregory J. Riely,Benjamin Solomon,Sai-Hong Ignatius Ou,Dong Wan Kim,Ravi Salgia,Panagiotis Fidias,Jeffrey A. Engelman,Leena Gandhi,Pasi A. Jänne,Daniel B. Costa,Geoffrey I. Shapiro,Patricia LoRusso,Katherine Ruffner,Patricia Stephenson,Yiyun Tang,Keith D. Wilner,Jeffrey W. Clark,Alice T. Shaw +23 more
TL;DR: Crizotinib is well tolerated with rapid, durable responses in patients with ALK-positive NSCLC and there seems to be potential for ongoing benefit after initial disease progression in this population, but a more formal definition of ongoing benefit in this context is needed.
Journal ArticleDOI
Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
Daniel D. Von Hoff,Patricia LoRusso,Charles M. Rudin,Josina C. Reddy,Robert L. Yauch,Raoul Tibes,Glen J. Weiss,Mitesh J. Borad,Christine L. Hann,Julie R. Brahmer,Howard Mackey,Bertram L. Lum,Walter C. Darbonne,James C. Marsters,Frederic J. de Sauvage,Jennifer A. Low +15 more
TL;DR: GDC-0449, an orally active small molecule that targets the hedgehog pathway, appears to have antitumor activity in locally advanced or metastatic basal-cell carcinoma.
Journal ArticleDOI
Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile
Jeffrey S. Hrkach,Daniel D. Von Hoff,Mir Mukkaram Ali,Elizaveta Andrianova,Jason Auer,Tarikh Christopher Campbell,David De Witt,Michael Figa,Maria Figueiredo,Allen Horhota,Susan Low,Kevin McDonnell,Erick Peeke,Beadle Retnarajan,Abhimanyu Sabnis,Edward Schnipper,Jeffrey J. Song,Young-Ho Song,Jason Summa,Douglas Tompsett,Greg Troiano,Tina Van Geen Hoven,James Wright,Patricia LoRusso,Philip W. Kantoff,Neil H. Bander,Christopher Sweeney,Omid C. Farokhzad,Robert Langer,Stephen E. Zale +29 more
TL;DR: Developing and clinical translation of a targeted polymeric nanoparticle (TNP) containing the chemotherapeutic docetaxel (DTXL) for the treatment of patients with solid tumors and initial clinical data indicated that DTXL-TNP displays a pharmacological profile differentiated from sb-DTXL.
Journal ArticleDOI
Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449
Charles M. Rudin,Christine L. Hann,John Laterra,Robert L. Yauch,Christopher A. Callahan,Ling Fu,Thomas Holcomb,Jeremy Stinson,Stephen E. Gould,Barbara Coleman,Patricia LoRusso,Daniel D. Von Hoff,Frederic J. de Sauvage,Jennifer A. Low +13 more
TL;DR: A 26-year-old man with metastatic medulloblastoma that was refractory to multiple therapies was treated with a novel hedgehog pathway inhibitor, GDC-0449; treatment resulted in rapid (although transient) regression of the tumor and reduction of symptoms.