C
Cook Adam
Researcher at Icos
Publications - 30
Citations - 435
Cook Adam is an academic researcher from Icos. The author has contributed to research in topics: DNA damage & Carboxylic acid. The author has an hindex of 7, co-authored 30 publications receiving 278 citations.
Papers
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Journal ArticleDOI
Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer.
Fell Jay Bradford,John P. Fischer,Brian R. Baer,James F. Blake,Karyn Bouhana,David Briere,Karin D. Brown,Laurence E. Burgess,Aaron C. Burns,Michael Burkard,Harrah Chiang,Mark Joseph Chicarelli,Cook Adam,John Gaudino,Jill Hallin,Lauren Hanson,Dylan P. Hartley,Hicken Erik James,Gary P. Hingorani,Ronald Jay Hinklin,Macedonio J. Mejia,Peter Olson,Jennifer N. Otten,Susan P. Rhodes,Martha Rodriguez,Pavel Y. Savechenkov,Darin Smith,Niranjan Sudhakar,Francis X. Sullivan,Tony Pisal Tang,Guy Vigers,Lance Wollenberg,James G. Christensen,Matthew A. Marx +33 more
TL;DR: The discovery of the clinical development candidate MRTX849 as a potent, selective covalent inhibitor of KRASG12C is described.
Patent
Compounds useful for inhibiting Chk1
Kathleen S. Keegan,Edward A. Kesicki,John Gaudino,Cook Adam,Cowen Scott Douglas,Laurence E. Burgess +5 more
TL;DR: Aryl and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed in this paper.
Patent
Aryl and heteroaryl urea chk1 inhibitors for use as radiosensitizers and chamosensitizers
Kathleen S. Keegan,Kesicki Edward A,Gaudino John Joseph,Cook Adam,Cowen Scott Douglas,Burgess Laurence Edward +5 more
TL;DR: Aryl and hetero-aryl substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed in this paper, where the methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer, chromosome segregation, or cell division also are disclosed.
Patent
7-phenoxychroman carboxylic acid derivatives
Cook Adam,Kevin W. Hunt,Robert Kirk Delisle,Todd Romoff,Christopher T. Clark,Ganghyeok Kim,Christopher P. Corrette,George A. Doherty,Laurence E. Burgess +8 more
TL;DR: In this paper, the DP2 receptor inhibitors of Formula I: (I) are defined as: A, A 1, R 1, R 1, A 7a, R 7a, R 7b, R 8 and R 10.
Patent
S piro [chroman - 4, 4 ' - imidazol] ones as beta - secretase inhibitors
TL;DR: In this article, spirochroman compounds of Formulas I and II were used to inhibit β-secretase cleavage of APP and were useful as therapeutic agents for treating neurodegenerative diseases.