Cornelis P. Vlaar

TL;DR: EHop-016 is identified as a compound that blocks the interaction of Rac with the GEF Vav in metastatic human breast cancer cells with an IC50 of ~1μM and inhibits the activation of the Rac downstream effector p21-activated kinase, extension of motile actin-based structures, and cell migration.

TL;DR: The pharmacokinetics and tissue distribution of MBQ-167 following intraperitoneal and oral single-dose administrations are reported and supports further preclinical evaluation of this drug as a potential anticancer therapeutic.

TL;DR: MBQ-167 as discussed by the authors is a dual inhibitor of Rac and Cdc42, small GTPases that are involved in cytoskeletal organization, cell cycle progression, and cell migration.

TL;DR: In this paper, a simple two-step procedure for the conversion of readily available phthalides to the corresponding benzoxazinones was developed, starting with ring-opening aminolysis to form a primary 2-hydroxymethylbenzamide, followed by reaction with bis(trifluoroacetoxy)iodobenzene (BTI) conveniently, provided a variety of 4-substituted benzoxinones.

TL;DR: Modafinil is an anti-narcoleptic drug used to treat excessive daytime sleepiness associated with sleep apnea and shift-work disorder and it is unique in its lack of significant side-effects or addiction-inducing properties.