J
Jean F. Ruiz-Calderon
Researcher at University of Puerto Rico
Publications - 6
Citations - 208
Jean F. Ruiz-Calderon is an academic researcher from University of Puerto Rico. The author has contributed to research in topics: Pharmacokinetics & Physiologically based pharmacokinetic modelling. The author has an hindex of 4, co-authored 6 publications receiving 103 citations. Previous affiliations of Jean F. Ruiz-Calderon include University of Puerto Rico, Río Piedras & University of Puerto Rico, Medical Sciences Campus.
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Journal ArticleDOI
Walls talk: Microbial biogeography of homes spanning urbanization
Jean F. Ruiz-Calderon,Humberto Cavallin,Se Jin Song,Atila Novoselac,Luis R. Pericchi,Jean N. Hernandez,Rafael Rios,OraLee H. Branch,Henrique dos Santos Pereira,Luciana C. Paulino,Martin J. Blaser,Rob Knight,Maria Gloria Dominguez-Bello +12 more
TL;DR: This study addresses the associations between architectural design and the microbial biogeography of households across a gradient of urbanization in South America and found urbanized spaces uniquely increase the content of human-associated microbes and decrease exposure to the environmental microbes with which humans have coevolved.
Journal ArticleDOI
Home chemical and microbial transitions across urbanization
Laura-Isobel McCall,Chris Callewaert,Chris Callewaert,Qiyun Zhu,Se Jin Song,Amina Bouslimani,Amina Bouslimani,Jeremiah J. Minich,Madeleine Ernst,Madeleine Ernst,Jean F. Ruiz-Calderon,Humberto Cavallin,Henrique dos Santos Pereira,Atila Novoselac,Jean N. Hernandez,Rafael Rios,Ora Lee H. Branch,Ora Lee H. Branch,Martin J. Blaser,Luciana C. Paulino,Pieter C. Dorrestein,Rob Knight,Maria Gloria Dominguez-Bello +22 more
TL;DR: The authors use metabolomics and sequencing to assess changes in chemicals and microbial communities, including fungi and microeukaryotes, across an urbanization gradient in South America, and indicate that urbanization has large-scale effects on chemical and microbial exposures and on the human microbiota.
Journal ArticleDOI
Naturalization of the microbiota developmental trajectory of Cesarean-born neonates after vaginal seeding
Se Jin Song,Jincheng Wang,Cameron Martino,Lingjing Jiang,Wesley K. Thompson,Liat Shenhav,Daniel McDonald,Clarisse Marotz,Paul R. Harris,Caroll Hernández,Nora Henderson,Elizabeth Ackley,Deanna Nardella,Charles Gillihan,Valentina Montacuti,William Schweizer,Melanie Jay,Joan Combellick,Haipeng Sun,Izaskun García-Mantrana,Fernando Gil Raga,Maria Carmen Collado,Juana I Rivera-Viñas,Maribel Campos-Rivera,Jean F. Ruiz-Calderon,Rob Knight,Maria Gloria Dominguez-Bello +26 more
TL;DR: This is the first study showing long-term naturalization of the microbiota of CS-born infants by restoring microbial exposure at birth, and provides evidence of the pluripotential nature of maternal vaginal fluids to provide pioneer bacterial colonizers for the newborn body sites.
Journal ArticleDOI
Characterization of the intestinal microbiota of the sea cucumber Holothuria glaberrima.
María Pagán-Jiménez,Jean F. Ruiz-Calderon,Maria Gloria Dominguez-Bello,José E. García-Arrarás +3 more
TL;DR: The results evidence that in the natural sea environment, there is intestinal segment differentiation in the microbiota of H. glaberrima, which is lost in artificial conditions, relevant for physiological studies, such as mechanisms of digestive regeneration, which might be affected by the microbiota.
Journal ArticleDOI
Pharmacokinetics of the Rac/Cdc42 Inhibitor MBQ-167 in Mice by Supercritical Fluid Chromatography–Tandem Mass Spectrometry
Maria Del Mar Maldonado,Gabriela Rosado-González,Joseph Bloom,Jorge Duconge,Jean F. Ruiz-Calderon,Eliud Hernandez-O'Farrill,Cornelis P. Vlaar,José F. Rodríguez-Orengo,Suranganie Dharmawardhane +8 more
TL;DR: The pharmacokinetics and tissue distribution of MBQ-167 following intraperitoneal and oral single-dose administrations are reported and supports further preclinical evaluation of this drug as a potential anticancer therapeutic.