C
Crawford James John
Researcher at Genentech
Publications - 4
Citations - 52
Crawford James John is an academic researcher from Genentech. The author has contributed to research in topics: Bruton's tyrosine kinase & Kinase. The author has an hindex of 2, co-authored 4 publications receiving 37 citations. Previous affiliations of Crawford James John include Hoffmann-La Roche.
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Patent
Heteroaryl pyridone and aza-pyridone compounds as inhibitors of btk activity
TL;DR: Heteroaryl pyridone and aza-pyride compounds of Formula I have been used for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions as discussed by the authors.
Journal ArticleDOI
Highly efficient on-DNA amide couplings promoted by micelle forming surfactants for the synthesis of DNA encoded libraries.
James H. Hunter,Matthew J. Anderson,Isaline F.S.F. Castan,Jessica S. Graham,Catherine L.A. Salvini,Harriet A. Stanway-Gordon,Crawford James John,Andrew Madin,Garry Pairaudeau,Michael J. Waring +9 more
TL;DR: In this article, a method for amide coupling using micelle forming surfactants, promoted by a modified linker, was proposed for coupling DNA-conjugated carboxylic acids with amines in solution, a procedure that is currently very inefficient.
Patent
Heteroaryl pyridone and aza-pyridone compounds
TL;DR: In this paper, aza-pyridone compounds, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, are provided, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk Kinase.
Patent
Heteroaryl pyridone and aza-pyridone compounds as inhibitors of bruton's tyrosine kinase
TL;DR: Heteroaryl pyridone and aza-pyride compounds of Formula I have been used for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions as discussed by the authors.