Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific, and target-oriented delivery of precise medicines Recently, there are a number of outstanding applications of the nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents etc) in the treatment of various diseases The current review, presents an updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs (eg, natural products) and selective diagnosis through disease marker molecules The opportunities and challenges of nanomedicines in drug delivery from synthetic/natural sources to their clinical applications are also discussed In addition, we have included information regarding the trends and perspectives in nanomedicine area

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Nano based drug delivery systems: recent developments and future prospects

X-ray photoelectron spectroscopy: Towards reliable binding energy referencing

Atmospheric-pressure non-equilibrium plasma jets (APNP-Js), which generate plasma in open space rather than in a confined discharge gap, have recently been a topic of great interest. In this paper, the development of APNP-Js will be reviewed. Firstly, the APNP-Js are grouped based on the type of gas used to ignite them and their characteristics are discussed in detail. Secondly, one of the most interesting phenomena of APNP-Js, the ?plasma bullet?, is discussed and its behavior described. Thirdly, the very recent developments on the behavior of plasma jets when launched in a controlled environment and pressure are also introduced. This is followed by a discussion on the interaction between plasma jets. Finally, perspectives on APNP-J research are presented.

https://iopscience.iop.org/article/10.1088/0963-0252/21/3/034005/pdf

On atmospheric-pressure non-equilibrium plasma jets and plasma bullets

Recent advances in ZnO nanostructures and thin films for biosensor applications: review.

Iron oxide nanoparticles (NPs) hold great promise for future biomedical applications because of their magnetic properties as well as other intrinsic properties such as low toxicity, colloidal stability, and surface engineering capability. Numerous related studies on iron oxide NPs have been conducted. Recent progress in nanochemistry has enabled fine control over the size, crystallinity, uniformity, and surface properties of iron oxide NPs. This review examines various synthetic approaches and surface engineering strategies for preparing naked and functional iron oxide NPs with different physicochemical properties. Growing interest in designed and surface-engineered iron oxide NPs with multifunctionalities was explored in in vitro/in vivo biomedical applications, focusing on their combined roles in bioseparation, as a biosensor, targeted-drug delivery, MR contrast agents, and magnetic fluid hyperthermia. This review outlines the limitations of extant surface engineering strategies and several developing strategies that may overcome these limitations. This study also details the promising future directions of this active research field.

Designed synthesis and surface engineering strategies of magnetic iron oxide nanoparticles for biomedical applications

Magnetic iron oxide nanoparticles as drug delivery system in breast cancer

Nanostructure of ZnO thin films prepared by reactive rf magnetron sputtering

Characterization of Al 2 O 3 /ZrO 2 composite coatings deposited on Zr-2.5Nb alloy by plasma electrolytic oxidation

This paper presents a new device generating high-voltage pulsed cold atmospheric plasma jets. With these plasmas, the quantity of atomic oxygen (and, accordingly, the chemical activity) is a lot higher than that in previous researches. The main characteristic of the new device is the usage of three tubular needle-type electrodes connected in parallel. By applying high-voltage pulses (with 20-30-kV amplitude, duration of hundreds of nanoseconds, and hundreds of pulses per second), three independent discharges are formed in the discharge room. The plasma-forming gas is He, with a low quantity of oxygen introduced through the high-voltage electrodes. Each discharge has an optimal percentage of 0.5 % vol. O2 in He, which maximizes the quantity of atomic oxygen in the plasma. The plasmas of the three discharges unite to a single jet though, which contains a quantity of atomic oxygen that is a lot higher than that of the plasma of each discharge. The emission spectra of the plasma jets show the maximization of the intensity of the O I 777 nm line when a concentration of 1.5% vol. O2 in He (three times higher than so far) is introduced in the plasma-forming gas.

Atomic Oxygen Maximization in High-Voltage Pulsed Cold Atmospheric Plasma Jets

Thermionic Vacuum Arc method (TVA) was used for the first time to prepare SiC thin films. This method is very suitable for deposition of high purity thin films with compact structure and extremely smooth in vacuum conditions. The nanocomposites were investigated using Transmission Electron Microscopy (TEM) analyses provided with HR-TEM and SAED facilities. The structure of the films can be indexed as following three forms: cubic structure of SiC (F4-3m) a = 0.4348 nm, cubic Si (Fd3m) a = 0.54307 nm and graphite (P63/mmc) a = 0.2456 nm; c = 0.6696 nm. The morphology, topography, wettability and wear properties were also performed by SEE system and by Raman Spectroscopy, increasing the interest for emerging applications.

Cristian P. Lungu

Papers

Magnetic iron oxide nanoparticles as drug delivery system in breast cancer

Nanostructure of ZnO thin films prepared by reactive rf magnetron sputtering

Characterization of Al 2 O 3 /ZrO 2 composite coatings deposited on Zr-2.5Nb alloy by plasma electrolytic oxidation

Atomic Oxygen Maximization in High-Voltage Pulsed Cold Atmospheric Plasma Jets

Investigation of the SiC thin films synthetized by Thermionic Vacuum Arc method (TVA)