The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function

Isolation of disaturated phosphatidylcholine with osmium tetroxide

Publisher Summary This chapter discusses the metabolism of molecular species of diacylglycerophospholipids. The glycerolipid composition of cell membranes and lipoproteins is metabolically adjusted to meet specific requirements, and it does not merely reflect the supply of different fatty acids in the diet or in the cell culture medium. However, adequate adjustment cannot always be possible, and under such conditions, the cellular activity can take place in a suboptimal physicochemical environment and characteristic symptoms of a disease state can appear. As the cellular lipid composition is subject to considerable dietary and pharmacological manipulation, there can be therapeutic alterations in the composition of the molecular species of the tissues and other animal species. The metabolism of the molecular species of the glycerophospholipids is intimately involved with the activity of the acyl transferases. Therapeutic alterations in the composition of the molecular species of the glycerolipids can be feasible and can yield beneficial results in the treatment of membrane diseases.

Metabolism of molecular species of diacylglycerophospholipids.

Phospholipase D-structure, regulation and function.

Molecular species of lecithins from various animal tissues.

The lecithins of the liver, lung, intestine, plasma, and red blood cells of rats were isolated and the major individual molecular species identified and estimated quantitatively by combined thin-la...

D. A. Gornall

Papers

Molecular species of lecithins of some functionally distinct rat tissues.