D
D.A. Hems
Researcher at St George's Hospital
Publications - 15
Citations - 684
D.A. Hems is an academic researcher from St George's Hospital. The author has contributed to research in topics: Vasopressin & Hepatocyte. The author has an hindex of 10, co-authored 15 publications receiving 674 citations.
Papers
More filters
Journal ArticleDOI
Fatty acid synthesis in liver and adipose tissue of normal and genetically obese (ob/ob) mice during the 24-hour cycle.
D.A. Hems,E A Rath,T R Verrinder +2 more
TL;DR: Light is shed on the relative significance of liver and adipose tissue in fatty acid synthesis in mice, on the mino importance of glucose in hepatic lipogenesis, and on the alterations in the rate of fatty acids synthesis in genetically obese mice.
Journal ArticleDOI
Stimulation by vasopressin, angiotensin and oxytocin of gluconeogenesis in hepatocyte suspensions.
TL;DR: The potency of the stimulatory effects of vasopressin and angiotensin on hepatic gluconeogenesis suggests they are operative in vivo and Ca2+ plays a role in the stimulation by these hormones.
Journal ArticleDOI
Rapid stimulation by vasopressin, oxytocin and angiotensin II of glycogen degradation in hepatocyte suspensions.
TL;DR: It is demonstrated that hepatocytes can respond to low concentrations of vasopressin and angiotensin II, i.e. these effects are likely to be relevant in the intact animal.
Journal ArticleDOI
The influence of vasopressin and related peptides on glycogen phosphorylase activity and phosphatidylinositol metabolism in hepatocytes
C J Kirk,L M Rodrigues,D.A. Hems +2 more
TL;DR: The relative abilities of seven vasopressin-like peptides to activate hepatic glycogen phosphorylase and stimulate phosphate incorporation into phosphatidylinositol were compared.
Journal ArticleDOI
Rapid stimulation, by vasopressin and adrenaline, of inorganic phosphate incorporation into phosphatidyl inositol in isolated hepatocytes.
TL;DR: The results reflect enhanced turnover of PI, with the stimulus acting to enhance the breakdown of PI to 1,2-diacylglycerol within the plasma membrane.