D
D A Purcell-Huynh
Researcher at University of California, Los Angeles
Publications - 3
Citations - 403
D A Purcell-Huynh is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Genetic linkage & Chromosome 20. The author has an hindex of 3, co-authored 3 publications receiving 401 citations.
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Journal ArticleDOI
Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q.
A V Lembertas,Louis Pérusse,Yvon C. Chagnon,Janis S. Fisler,Craig H Warden,D A Purcell-Huynh,F. T. Dionne,Jacques Gagnon,André Nadeau,Aldons J. Lusis,Claude Bouchard +10 more
TL;DR: Analysis of NZB/BINJ x SM/J intercross mice located a quantitative trait locus (QTL) for obesity on distal mouse chromosome 2, in a region syntenic with a large region of human chromosome 20, showing linkage to percent body fat and fat mass.
Journal ArticleDOI
Genetic factors in lipoprotein metabolism. Analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approach.
D A Purcell-Huynh,A. Weinreb,Lawrence W. Castellani,Margarete Mehrabian,Mark H. Doolittle,Aldon J. Lusis +5 more
TL;DR: PlutoAII levels were linked to the apoAII gene and were highly correlated with plasma HDL cholesterol levels (r = 0.63, P =0.0001), indicating that apOAII expression influences LDL cholesterol levels.
Journal ArticleDOI
Evidence for linkage of the apolipoprotein A-II locus to plasma apolipoprotein A-II and free fatty acid levels in mice and humans
Craig H Warden,Aaron Daluiski,Xiangdong Bu,D A Purcell-Huynh,C De Meester,B H Shieh,Donald L. Puppione,R M Gray,Gerald M. Reaven,Yi Chen +9 more
TL;DR: Evidence is provided that, in a backcross between strains Mus spretus and C57BL/6J, apoAII levels correlate with plasma FFA concentrations on both chow and high-fat diets and that apoCII levels are linked to the apo AII gene, a gene that controls plasma apo aII levels, and that APOAII influences, by an unknown mechanism, plasma F FA levels.