Yvon C. Chagnon

TL;DR: This is the tenth update of the human obesity gene map, incorporating published results up to the end of October 2003 and continuing the previous format.

TL;DR: There is an association between a deficient GR function, defined as a poor feedback regulation of the HPA axis activity, and a polymorphic restriction site at the GR gene locus, and an abnormal control of HPAaxis function due to genetic alterations may contribute to the pathogenesis of abdominal obesity.

TL;DR: Comparisons across the complete, random, and obese samples suggest that some regions are specific to BP and others may involve obesity (eg, pleiotropy, epistasis, or gene-environment interaction).

TL;DR: Analysis of NZB/BINJ x SM/J intercross mice located a quantitative trait locus (QTL) for obesity on distal mouse chromosome 2, in a region syntenic with a large region of human chromosome 20, showing linkage to percent body fat and fat mass.

TL;DR: The three markers encompassing the UCP2 locus and spanning a 5 cM region on 11q13 are linked to resting energy expenditure in adult humans and the evidence is strong enough to warrant a search for DNA sequence variation in the gene itself.