Role of the hydrophobic effect in stability of site-specific protein-DNA complexes

Calorimetric determination of enthalpies of solution of slightly soluble liquids II. Enthalpy of solution of some hydrocarbons in water and their use in establishing the temperature dependence of their solubilities

There is a continued desire in biomedical research to reduce the number and duration of design cycles required to optimize lead compounds into high-quality chemical probes or safe and efficacious drug candidates. The insightful application of impactful molecular design elements is one approach toward achieving this goal. The replacement of a CH group with a N atom in aromatic and heteroaromatic ring systems can have many important effects on molecular and physicochemical properties and intra- and intermolecular interactions that can translate to improved pharmacological profiles. In this Perspective, the “necessary nitrogen atom” is shown to be a versatile high-impact design element for multiparameter optimization, wherein ≥10-, 100-, or 1000-fold improvement in a variety of key pharmacological parameters can be realized.

The Necessary Nitrogen Atom: A Versatile High-Impact Design Element for Multiparameter Optimization

Determination of the aqueous solubility of polynuclear aromatic hydrocarbons by a coupled column liquid chromatographic technique

THE solubilities in water of C1–C8 paraffin and branchedchain paraffin, 4 cycloparaffin, and 5 aromatic hydrocarbons have been determined using a gas-liquid partition chromatographic technique.

Solubility in Water of C 1 –C 9 Hydrocarbons

F o r the determination of individual mass transfer coeff ic ients for the benzene-water system, the mutual solubility of the components is required. T h i s paper dea ls with the solubility of benzene in water. T h e interpretation by Seidell (23) of the then-available portion of the present (1, 3-5, 7-19, 21-23, 25, 26) data on the solubility of benzene in water indicated a relationship that continually increased with temperature in a manner similar t o h i s other interpretations on the solubility of hydrocarbons in water. T h e more recent data of Bohon and Claussen (4) were the first to indicate a minimurn in the solubility curve for benzene (and other aromatic compounds), although Hill (13) suspected one. Taken a s a whole, the avai lable data might have been considered discordant. As a precise analytical technique for the analysis of benzene in water was needed for mass transfer s tudies , it was decided t o demonstrate and prove the technique by a redetermination of the solubility relationship. Ultraviolet spectrophotometry was selected a s the analytical tool. Study and experience indicated that the analytical technique had to b e developed with great care to avoid errors due to excess ive volatility, such as found by Saylor, Stuckey, and Gross (22), to improper calibration, to temperature-induced hazes , and perhaps to wall adsorption effects.

D. Arnold

Papers

Solubility of Benzene in Water.