D
D. B. Couch
Researcher at Research Triangle Park
Publications - 2
Citations - 164
D. B. Couch is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Chinese hamster ovary cell & Gene mutation. The author has an hindex of 2, co-authored 2 publications receiving 163 citations.
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The use of Chinese hamster ovary cells to quantify specific locus mutation and to determine mutagenicity of chemicals. A report of the gene-tox program.
TL;DR: The GENE-TOX Group on Specific Gene Mutations in Chinese Hamster Ovary (CHO) Cells has evaluated the use of mutational systems in these cells for identification of mutagenic chemicals, finding the CHO/HGPRT assay has a sound genetic and biochemical basis for quantifying specific locus mutation reproducibly.
Utilization of a quantitative mammalian cell mutation system, CHO/HGPRT, in experimental mutagenesis and genetic toxicology
TL;DR: Evidence for the genetic origin of mutation induction in the CHO/HGPRT system; dose-response relationship for EMS-mediated mutation induction and cell lethality; apparent dosimetry of EMS-induced mutagenesis; structure-activity relationship of alkylating agents and ICR compounds; mutagenicity and cytotoxicity of congeners of two classes of nitrosi compounds.