The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

Mitotic kinesin inhibitors

The chemistry of vinyl sulphones

Covering: July 1998 to the end of July 1999. Previous review: J. Chem. Soc., Perkin Trans. 1, 1999, 641.

The synthesis of thiols, selenols, sulfides, selenides, sulfoxides, selenoxides, sulfones and selenones

The chemistry of acetylenic and allenic sulfones

Synthesis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammatory and analgesic agents.

A Novel Route for the Synthesis of Unsaturated Oxo Sulfones and Bissulfones

Cyclohexenone carboxylates. a versatile source for fused isoxazoles and pyrazoles

6,8Diaryl 6,7-dihydrocarba/.ole (4), 6,8diaryl 6,7,8,9, terahydrocarbazole (7), 6,8diary 1 carba/.olc (8) were obtaüied from the Fischer indole cyclization of 6 carbcthoxy3,5diarylcyclohex2-enI -one (1).

An efficient synthesis of 6,8-diarylcarbazoles via fischer indole cyclizations

The reaction of semicarbazones of 3,5-diphenylcyclohex-2-enone 2 and 3,5-diphenylcyclohexanone 8 with selenium dioxide and thionyl chloride resulted in annelated 1,2,3-selena- and thia-diazoles 3, 4, 5, 9 and 10.

D. Bhaskar Reddy

Papers

A Novel Route for the Synthesis of Unsaturated Oxo Sulfones and Bissulfones

Cyclohexenone carboxylates. a versatile source for fused isoxazoles and pyrazoles

An efficient synthesis of 6,8-diarylcarbazoles via fischer indole cyclizations

Synthesis of Annelated 1,2,3-Selena- or -Thia-diazoles

A simple strategy for styryl sulfonyl ethynylogues and 1,4-diarylbut-1-en-3-ynes