D
D.C. Phillips
Researcher at AbbVie
Publications - 2
Citations - 478
D.C. Phillips is an academic researcher from AbbVie. The author has contributed to research in topics: Navitoclax & Small molecule. The author has an hindex of 2, co-authored 2 publications receiving 436 citations.
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Journal ArticleDOI
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).
Joel D. Leverson,Haichao Zhang,Jun Chen,Stephen K. Tahir,D.C. Phillips,John Xue,Paul Nimmer,Sha S. Jin,Morey L. Smith,Yu Xiao,Peter Kovar,Atsushi Tanaka,Milan Bruncko,George S. Sheppard,Leyu Wang,Sarah Gierke,Lorna Kategaya,Daniel Anderson,Chihunt Wong,Jeffrey Eastham-Anderson,Mary J. C. Ludlam,Deepak Sampath,Wayne J. Fairbrother,Ingrid E. Wertz,Saul H. Rosenberg,Chris Tse,Steven W. Elmore,Andrew J. Souers +27 more
TL;DR: This work represents the first description of small-molecule MCL-1 inhibitors with sufficient potency to induce clear on-target cellular activity, and demonstrates the utility of these molecules as chemical tools for dissecting the basic biology of M CL-1.
Journal ArticleDOI
Loss in MCL-1 function sensitizes non-Hodgkin's lymphoma cell lines to the BCL-2-selective inhibitor venetoclax (ABT-199)
D.C. Phillips,Yu Xiao,Lloyd T. Lam,E Litvinovich,Lisa Roberts-Rapp,Andrew J. Souers,Joel D. Leverson +6 more
TL;DR: It is shown that BCL2 status is predictive of venetoclax potency in NHL not only as a single agent, but also in the adjuvant setting with anti-tumorigenic agents that inhibit MCL-1 function.