Ingrid E. Wertz

TL;DR: A novel ubiquitin ligase domain is defined and two sequential mechanisms by which A20 downregulates NF-κB signalling are identified, both of which participate in mediating a distinct regulatory effect.

TL;DR: COP1 is a critical negative regulator of p53 and represents a new pathway for maintaining p53 at low levels in unstressed cells and is identified as a p53-inducible gene.

TL;DR: Highlights suggest that profiling the FBW7 and MCL1 status of tumours, in terms of protein levels, messenger RNA levels and genetic status, could be useful to predict the response of patients to antitubulin chemotherapeutics.

TL;DR: This work has developed linkage-specific antibodies that recognize polyubiquitin chains joined through lysine 63 (K63) or 48 (K48) and uses these antibodies to demonstrate that RIP1, which is essential for tumor necrosis factor-induced NF-kappaB activation, and IRAK1, who participates in signaling by interleukin-1beta and Toll-like receptors, both undergo polyubiquein editing in stimulated cells.

TL;DR: The adaptor protein Bcl10 promotes activation of NF-κB transcription factors through paracaspase- and UBC13-dependent ubiquitination of NEMO.