D
D.M. Blow
Researcher at Laboratory of Molecular Biology
Publications - 13
Citations - 2230
D.M. Blow is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Side chain & Hydrogen bond. The author has an hindex of 12, co-authored 13 publications receiving 2222 citations.
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Journal ArticleDOI
The detection of sub‐units within the crystallographic asymmetric unit
Michael G. Rossmann,D.M. Blow +1 more
TL;DR: In this article, Rossmann and Blow describe how they have detected the existence of partial, approximate symmetry from a knowledge of the intensities alone, and the effect of noncrystallographic symmetry, whether partial or total, results in decreasing the size of the structure to be determined, while the number of observable intensities remains the same.
Journal ArticleDOI
Structure of crystalline -chymotrypsin. V. The atomic structure of tosyl- -chymotrypsin at 2 A resolution.
Jens J. Birktoft,D.M. Blow +1 more
TL;DR: Refined atomic co-ordinates for tosyl-α-chymotrypsin have been obtained by computational refinement of co-coordinates derived from a carefully built atomic model as mentioned in this paper.
Journal ArticleDOI
Structure of crystalline alpha-chymotrypsin. 3. Crystallographic studies of substrates and inhibitors bound to the active site of alpha-chymotrypsin.
TL;DR: A detailed analysis of the binding of N-formyl-l-tryptophan to the active site of α-chymotrypsin shows that the indolyl side chain lies in a hydrophobic pocket or slit, which accounts for the specificity of this enzyme for binding arginine or lysine side chains.
Journal ArticleDOI
Determination of phases by the conditions of non-crystallographic symmetry
Michael G. Rossmann,D.M. Blow +1 more
Journal ArticleDOI
An X-ray diffraction study of inhibited derivatives of α-chymotrypsin
TL;DR: In this article, the positions and orientations of the inhibitor groups were determined from difference Fourier projections calculated using phase angles derived from a single isomorphous heavy-atom derivative.