D
D. M. Zimmerman
Researcher at Research Triangle Park
Publications - 14
Citations - 569
D. M. Zimmerman is an academic researcher from Research Triangle Park. The author has contributed to research in topics: JDTic & Opioid receptor. The author has an hindex of 11, co-authored 14 publications receiving 557 citations.
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Journal ArticleDOI
Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.
James B. Thomas,Robert N. Atkinson,Richard B. Rothman,Scott E. Fix,S. W. Mascarella,Noelle Vinson,Heng Xu,Christina M. Dersch,YF Lu,B. E. Cantrell,D. M. Zimmerman,Frank I. Carroll +11 more
TL;DR: A structurally novel opioid kappa receptor selective ligand has been identified and demonstrated high affinity and highly potent and selective kappa antagonism in the [(35)S]GTP-gamma-S assay using cloned opioid receptors.
Journal ArticleDOI
Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro
P Miu,K.R Jarvie,V Radhakrishnan,Mary Gates,Ann-Marie Ogden,Paul L. Ornstein,Hamideh Zarrinmayeh,Ken H. Ho,D Peters,J Grabell,A Gupta,D. M. Zimmerman,David Bleakman +12 more
TL;DR: It is demonstrated that LY392098 and LY404187 allosterically potentiate responses mediated by human AMPA receptor ion channels expressed in HEK 293 cells in vitro.
Journal ArticleDOI
Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.
James B. Thomas,Robert N. Atkinson,Noelle Vinson,Jennifer L. Catanzaro,Carin Perretta,Scott E. Fix,S. W. Mascarella,Richard B. Rothman,Heng Xu,Christina M. Dersch,B. E. Cantrell,D. M. Zimmerman,Frank I. Carroll +12 more
TL;DR: The results suggest that, like other kappa opioid antagonists such as nor-BNI and GNTI, JDTic requires a second basic amino group to express potent and selective kappa antagonist activity in the [(35)S]GTPgammaS functional assay.
Journal ArticleDOI
Biarylpropylsulfonamides as novel, potent potentiators of 2-amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic acid (AMPA) receptors.
Paul L. Ornstein,D. M. Zimmerman,Macklin Brian Arnold,Thomas J. Bleisch,B. E. Cantrell,Richard Lee Simon,Hamideh Zarrinmayeh,Baker,Mary Gates,Joseph P. Tizzano,David Bleakman,Allan Mandelzys,K.R Jarvie,Ken H. Ho,Michele Deverill,Rajender Kamboj +15 more
Journal ArticleDOI
Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine
James B. Thomas,Michael J. Fall,Julie B. Cooper,Richard B. Rothman,S. W. Mascarella,Heng Xu,John S. Partilla,Christina M. Dersch,K. B. Mccullough,B. E. Cantrell,D. M. Zimmerman,F. I. Carroll +11 more
TL;DR: According to its ability to inhibit agonist stimulated binding of [35S]GTPgammaS at all three opioid receptors, compound 8 behaves as a mu/kappa opioid receptor pure antagonist with negligible affinity for the delta receptor.