D. Machin

TL;DR: Prophylactic cranial irradiation (PCI) reduces the risk of cranial metastasis in small cell lung cancer (SCLC), but the magnitude and value of this reduction, the risks of radiation morbidity and whether PCI influences survival are unclear as discussed by the authors.

TL;DR: A checklist for points that should be covered in protocols involving QoL assessment is provided, and examples are given from a range of current MRC Cancer Trials Office protocols, which it is proposed might act as templates when writing new protocols.

TL;DR: This paper reports on the proceedings of a symposium aimed at summarising and discussing some of the most contentious methodological and statistical issues in QoL and economic evaluations.

TL;DR: This model identified a high risk group of patients with an excess death rate of more than 15% in the second week after starting chemotherapy, and Radford et als' suggestion that high risk patients be given half doses of drugs at the first cycle should be tested in a randomised clinical trial.

TL;DR: It is suggested that 3 years should be adopted as the standard definition of LTS in SCLC, and that studies should always report limited and extensive stage patients separately.