D
D. Shealy
Publications - 2
Citations - 612
D. Shealy is an academic researcher. The author has contributed to research in topics: Cytokine & Crohn's disease. The author has an hindex of 2, co-authored 2 publications receiving 603 citations.
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Journal Article
A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease.
S. E. Plevy,Carol J. Landers,John Prehn,N M Carramanzana,Richard L. Deem,D. Shealy,Stephan R. Targan +6 more
TL;DR: Observations suggest that TNF-alpha may be a cofactor for mucosal Th1 responses, and improvement in clinical parameters and intestinal inflammation induced by cA2 in Crohn's disease may be mediated by down-regulation of mucosa Th1 cytokines.
Journal ArticleDOI
Infliximab induces potent anti-inflammatory and local immunomodulatory activity but no systemic immune suppression in patients with Crohn's disease.
Freddy Cornillie,D. Shealy,G. D'Haens,K. Geboes,G. Van Assche,Jan Ceuppens,C. Wagner,Thomas F. Schaible,S. E. Plevy,S. R. Targan,Paul Rutgeerts +10 more
TL;DR: Anti‐TNFα therapy with infliximab is effective for Crohn’s disease and neutralizes the biological activities of TNFα, a cytokine involved in host‐defence against certain infections.