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Stephan R. Targan
Researcher at Mayo Clinic
Publications - 46
Citations - 1870
Stephan R. Targan is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Ulcerative colitis & Inflammatory bowel disease. The author has an hindex of 16, co-authored 46 publications receiving 1841 citations. Previous affiliations of Stephan R. Targan include University of California, Los Angeles & University of Paris.
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Journal Article
A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease.
S. E. Plevy,Carol J. Landers,John Prehn,N M Carramanzana,Richard L. Deem,D. Shealy,Stephan R. Targan +6 more
TL;DR: Observations suggest that TNF-alpha may be a cofactor for mucosal Th1 responses, and improvement in clinical parameters and intestinal inflammation induced by cA2 in Crohn's disease may be mediated by down-regulation of mucosa Th1 cytokines.
Journal ArticleDOI
Familial empirical risks for inflammatory bowel disease: differences between Jews and non-Jews.
TL;DR: These different empirical risks for relatives of Jewish and non-Jewish probands allow rejection of single Mendelian gene models for inflammatory bowel disease, but are consistent with several alternative genetic models.
Journal ArticleDOI
Neutrophil cytoplasmic antibodies: A link between primary sclerosing cholangitis and ulcerative colitis
Richard H. Duerr,Richard H. Duerr,Stephan R. Targan,Stephan R. Targan,Carol J. Landers,Carol J. Landers,Nicholas F. LaRusso,Nicholas F. LaRusso,Karen L. Lindsay,Karen L. Lindsay,Russell H. Wiesner,Russell H. Wiesner,Fergus Shanahan,Fergus Shanahan +13 more
TL;DR: It is concluded that neutrophil cytoplasmic antibodies in ulcerative colitis and primary sclerosing cholangitis may be markers of shared underlying immunopathogenic mechanisms and Identification of the target antigen(s) may facilitate understanding of the underlying immune response and development of an improved disease marker assay.
Journal Article
Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+, CD45RBhigh T cells to SCID recipients.
R. Aranda,Beate C. Sydora,P. L. Mcallister,Scott W. Binder,Hui Ying Yang,Stephan R. Targan,Mitch Kronenberg +6 more
TL;DR: It is hypothesized that the ability of pathogenic cells to traffic to the intestine and mediate colitis may be driven by T cell reactivity to bacteria or bacterial products.
Journal ArticleDOI
Pouchitis disease course after orthotopic liver transplantation in patients with primary sclerosing cholangitis and an ileal pouch-anal anastomosis.
Bradley J. Zins,William J. Sandborn,William J. Sandborn,William J. Sandborn,Christophe Penna,Christophe Penna,Christophe Penna,Carol J. Landers,Carol J. Landers,Carol J. Landers,Stephan R. Targan,Stephan R. Targan,Stephan R. Targan,William J. Tremaine,William J. Tremaine,William J. Tremaine,Russell H. Wiesner,Roger R. Dozois,Roger R. Dozois,Roger R. Dozois +19 more
TL;DR: Pouchitis occurs frequently in patients with primary sclerosing cholangitis and an ileal pouch-anal anastomosis for ulcerative colitis and Liver transplantation does not alter the disease course of pouchitis for most of these patients.