D
D Upchurch
Researcher at University of Kentucky
Publications - 2
Citations - 777
D Upchurch is an academic researcher from University of Kentucky. The author has contributed to research in topics: CD34 & Genetic enhancement. The author has an hindex of 2, co-authored 2 publications receiving 737 citations.
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Journal ArticleDOI
The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells
Craig T. Jordan,D Upchurch,Stephen J. Szilvassy,Monica L. Guzman,Dianna S. Howard,AL Pettigrew,Todd E. Meyerrose,Randall M. Rossi,Barry Grimes,David A. Rizzieri,Selina M. Luger,Gordon L. Phillips +11 more
TL;DR: Data indicate that CD123 represents a unique marker for primitive leukemic stem cells and it is proposed that targeting of CD123 may be a promising strategy for the preferential ablation of AML cells.
Journal ArticleDOI
Genetic manipulation of primitive leukemic and normal hematopoietic cells using a novel method of adenovirus-mediated gene transfer
Dianna S. Howard,DA Rizzierri,Barry Grimes,D Upchurch,Gordon L. Phillips,AK Stewart,JR Yannelli,Craig T. Jordan +7 more
TL;DR: VPC-mediated gene transfer is an effective means of transducing normal and AML cells, including those with a highly primitive phenotype, and suggests that transient genetic manipulation of primitive hematopoietic cells can readily be achieved and should therefore permit a variety of research and clinical endeavors.