D
Dah-Yuu Lu
Researcher at China Medical University (Taiwan)
Publications - 62
Citations - 2439
Dah-Yuu Lu is an academic researcher from China Medical University (Taiwan). The author has contributed to research in topics: Glioma & Nitric oxide synthase. The author has an hindex of 29, co-authored 58 publications receiving 2077 citations. Previous affiliations of Dah-Yuu Lu include China Medical University (PRC) & Carnegie Mellon University.
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Journal ArticleDOI
Docosahexaenoic Acid Suppresses Neuroinflammatory Responses and Induces Heme Oxygenase-1 Expression in BV-2 Microglia: Implications of Antidepressant Effects for Omega-3 Fatty Acids
TL;DR: This study provides a novel implication of the antidepressant mechanisms of DHA, which reduced expressions of tumor necrosis factor-α, interleukin-6, nitric oxide synthase, and cyclo-oxygenase-2, and induced upregulation of heme oxygenase-1 (HO-1) in BV-2 microglia.
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Inhibition of Hypoxia-Induced Increase of Blood-Brain Barrier Permeability by YC-1 through the Antagonism of HIF-1α Accumulation and VEGF Expression
TL;DR: Results indicate that YC-1 may inhibit HIF-1α accumulation and VEGF production, which in turn protect BBB from injury caused by hypoxia, and protect the BBB against ischemia/reperfusion-induced injury.
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Berberine suppresses neuroinflammatory responses through AMP-activated protein kinase activation in BV-2 microglia
TL;DR: It is shown that berberine represses proinflammatory responses through AMP‐activated protein kinase (AMPK) activation in BV‐2 microglia and significantly induces AMPK signaling pathways activation, which is involved in anti‐neuroinflammation.
Journal ArticleDOI
SDF-1alpha up-regulates interleukin-6 through CXCR4, PI3K/Akt, ERK, and NF-kappaB-dependent pathway in microglia.
Dah-Yuu Lu,Chih-Hsin Tang,Wei-Lan Yeh,Kar-Lok Wong,Chih-Peng Lin,Yi-Hung Chen,Chih Ho Lai,Yuh-Fung Chen,Yuk-Man Leung,Wen-Mei Fu +9 more
TL;DR: It is demonstrated that SDF-1alpha enhanced IL-6 production in both primary cultured microglia and BV-2 micro glia and further investigated the signaling pathway involved in IL- 6 production stimulated by SDF/CXCR4 inmicroglia, providing additional support for the notion that Sdf-1 alpha plays a regulatory role in microglian activation.
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Hypoxia-induced iNOS expression in microglia is regulated by the PI3-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1α
TL;DR: It is demonstrated that hypoxia induced iNOS expression by regulation of HIF-1alpha in microglia is regulated by the phosphatidylinositol 3-kinase/AKT/ mammalian target of rapamycin (mTOR) signaling pathway and activation of Hypoxia inducible factor-1 alpha (HIF- 1alpha) during cerebral ischemia.