(1981). Practical Nonparametric Statistics (2nd ed.) Technometrics: Vol. 23, No. 4, pp. 415-416.

Practical Nonparametric Statistics (2nd ed.)

Cloud can be defined as a new computing paradigm that provides scalable, on-demand, and virtualized resources for users. In this style of computing, users can access a shared pool of computing resources which are provisioned with minimal management efforts of users. Yet there are some obstacles and concerns about the use of clouds. Guaranteeing quality of service U+0028 QoS U+0029 by service providers can be regarded as one of the main concerns for companies tending to use it. Service provisioning in clouds is based on service level agreements representing a contract negotiated between users and providers. According to this contract, if a provider cannot satisfy its agreed application requirements, it should pay penalties as compensation. In this paper, we intend to carry out a comprehensive survey on the models proposed in literature with respect to the implementation principles to address the QoS guarantee issue.

Toward cloud computing QoS architecture: analysis of cloud systems and cloud services

Healthy articular cartilage, covering the ends of bones in major joints such as hips and knees, presents the most efficiently-lubricated surface known in nature, with friction coefficients as low as 0.001 up to physiologically high pressures. Such low friction is indeed essential for its well-being. It minimizes wear-and-tear and hence the cartilage degradation associated with osteoarthritis, the most common joint disease, and, by reducing shear stress on the mechanotransductive, cartilage-embedded chondrocytes (the only cell type in the cartilage), it regulates their function to maintain homeostasis. Understanding the origins of such low friction of the articular cartilage, therefore, is of major importance in order to alleviate disease symptoms, and slow or even reverse its breakdown. This progress report considers the relation between frictional behavior and the cellular mechanical environment in the cartilage, then reviews the mechanism of lubrication in the joints, in particular focusing on boundary lubrication. Following recent advances based on hydration lubrication, a proposed synergy between different molecular components of the synovial joints, acting together in enabling the low friction, has been proposed. Additionally, recent development of natural and bio-inspired lubricants is reviewed.

Recent Progress in Cartilage Lubrication.

Cloud computing and Internet of Things (IoT) are computing technologies that provide services to consumers and businesses, allowing organizations to become more agile and flexible. Therefore, ensuring quality of service (QoS) through service-level agreements (SLAs) for such cloud-based services is crucial for both the service providers and service consumers. As SLAs are critical for cloud deployments and wider adoption of cloud services, the management of SLAs in cloud and IoT has thus become an important and essential aspect. This paper investigates the existing research on the management of SLAs in IoT applications that are based on cloud services. For this purpose, a systematic mapping study (a well-defined method) is conducted to identify the published research results that are relevant to SLAs. This paper identifies 328 primary studies and categorizes them into seven main technical classifications: SLA management, SLA definition, SLA modeling, SLA negotiation, SLA monitoring, SLA violation and trustworthiness, and SLA evolution. This paper also summarizes the research types, research contributions, and demographic information in these studies. The evaluation of the results shows that most of the approaches for managing SLAs are applied in academic or controlled experiments with limited industrial settings rather than in real industrial environments. Many studies focus on proposal models and methods to manage SLAs, and there is a lack of focus on the evolution perspective and a lack of adequate tool support to facilitate practitioners in their SLA management activities. Moreover, the scarce number of studies focusing on concrete metrics for qualitative or quantitative assessment of QoS in SLAs urges the need for in-depth research on metrics definition and measurements for SLAs.

Management of Service Level Agreements for Cloud Services in IoT: A Systematic Mapping Study

Semantic-based QoS management in cloud systems

Tribological surgical adjuvants constitute a therapeutic discipline made possible by surgical advances in the treatment of damaged articular cartilage beyond palliative care. The purpose of this study is to analyze interactions between hyaluronic acid and phospholipid molecules, and the formation of geometric forms, that play a role in the facilitated lubrication of synovial joint organ systems. The analysis includes an evaluation of the pathologic state to detail conditions that may be encountered by adjuvants during surgical convalescence. The synovial fluid changes in pH, hyaluronic acid polydispersity, and phospholipid concentration associated with osteoarthritis are presented as features that influence the lubricating properties of adjuvant candidates. Molecular dynamic simulation studies are presented, and the Rouse model is deployed, to rationalize low molecular weight hyaluronic acid behavior in an osteoarthritic environment of increased pH and phospholipid concentration. The results indicate that the hyaluronic acid radius of gyration time evolution is both pH- and phospholipid concentration-dependent. Specifically, dipalmitoylphosphatidylcholine induces hydrophobic interactions in the system, causing low molecular weight hyaluronic acid to shrink and at high concentration be absorbed into phospholipid vesicles. Low molecular weight hyaluronic acid appears to be insufficient for use as a tribological surgical adjuvant because an increased pH and phospholipid concentration induces decreased crosslinking that prevents the formation of supramolecular lubricating forms. Dipalmitoylphosphatidylcholine remains an adjuvant candidate for certain clinical situations. The need to reconcile osteoarthritic phenotypes is a prerequisite that should serve as a framework for future adjuvant design and subsequent tribological testing.

https://www.mdpi.com/1420-3049/22/9/1436/pdf

Molecular Dynamic Analysis of Hyaluronic Acid and Phospholipid Interaction in Tribological Surgical Adjuvant Design for Osteoarthritis.

Many global distributed cloud computing applications and services running over the Internet, between globally dispersed clients and servers, will require certain levels of Quality of Service (QoS) in order to deliver and give a sufficiently smooth user experience. This would be essential for real-time streaming multimedia applications like online gaming and watching movies on a pay as you use basis hosted in a cloud computing environment. However, guaranteeing or even predicting QoS in global and diverse networks supporting complex hosting of application services is a very challenging issue that needs a stepwise refinement approach to be solved as the technology of cloud computing matures. In this paper, we investigate if latency in terms of simple Ping measurements can be used as an indicator for other QoS parameters such as jitter and throughput. The experiments were carried out on a global scale, between servers placed in universities in Denmark, Poland, Brazil and Malaysia. The results show some correlation between latency and throughput, and between latency and jitter, even though the results are not completely consistent. As a side result, we were able to monitor the changes in QoS parameters during a number of 24-hour periods. This is also a first step towards defining QoS parameters to be included in Service Level Agreements for cloud computing in the foreseeable future.

Assessing Measurements of QoS for Global Cloud Computing Services

The analysis and processing of ECG signals are a key approach in the diagnosis of cardiovascular diseases. The main field of work in this area is classification, which is increasingly supported by machine learning-based algorithms. In this work, a deep neural network was developed for the automatic classification of primary ECG signals. The research was carried out on the data contained in a PTB-XL database. Three neural network architectures were proposed: the first based on the convolutional network, the second on SincNet, and the third on the convolutional network, but with additional entropy-based features. The dataset was divided into training, validation, and test sets in proportions of 70%, 15%, and 15%, respectively. The studies were conducted for 2, 5, and 20 classes of disease entities. The convolutional network with entropy features obtained the best classification result. The convolutional network without entropy-based features obtained a slightly less successful result, but had the highest computational efficiency, due to the significantly lower number of neurons.

ECG Signal Classification Using Deep Learning Techniques Based on the PTB-XL Dataset.

Lubrication of articular cartilage is a complex multiscale phenomenon in synovial joint organ systems. In these systems, synovial fluid properties result from synergistic interactions between a variety of molecular constituent. Two molecular classes in particular are of importance in understanding lubrication mechanisms: hyaluronic acid and phospholipids. The purpose of this study is to evaluate interactions between hyaluronic acid and phospholipids at various functionality levels during normal and pathological synovial fluid conditions. Molecular dynamic simulations of hyaluronic acid and phospholipids complexes were performed with the concentration of hyaluronic acid set at a constant value for two organizational forms, extended (normal) and coiled (pathologic). The results demonstrated that phospholipids affect the crosslinking mechanisms of hyaluronic acid significantly and the influence is higher during pathological conditions. During normal conditions, hyaluronic acid and phospholipid interactions seem to have no competing mechanism to that of the interaction between hyaluronic acid to hyaluronic acid. On the other hand, the structures formed under pathologic conditions were highly affected by phospholipid concentration.

/pdf/anomalous-behavior-of-hyaluronan-crosslinking-due-to-the-542ufj7du7.pdf

Anomalous Behavior of Hyaluronan Crosslinking Due to the Presence of Excess Phospholipids in the Articular Cartilage System of Osteoarthritis.

The electrocardiogram (ECG) is considered a fundamental of cardiology. The ECG consists of P, QRS, and T waves. Information provided from the signal based on the intervals and amplitudes of these waves is associated with various heart diseases. The first step in isolating the features of an ECG begins with the accurate detection of the R-peaks in the QRS complex. The database was based on the PTB-XL database, and the signals from Lead I–XII were analyzed. This research focuses on determining the Few-Shot Learning (FSL) applicability for ECG signal proximity-based classification. The study was conducted by training Deep Convolutional Neural Networks to recognize 2, 5, and 20 different heart disease classes. The results of the FSL network were compared with the evaluation score of the neural network performing softmax-based classification. The neural network proposed for this task interprets a set of QRS complexes extracted from ECG signals. The FSL network proved to have higher accuracy in classifying healthy/sick patients ranging from 93.2% to 89.2% than the softmax-based classification network, which achieved 90.5–89.2% accuracy. The proposed network also achieved better results in classifying five different disease classes than softmax-based counterparts with an accuracy of 80.2–77.9% as opposed to 77.1% to 75.1%. In addition, the method of R-peaks labeling and QRS complexes extraction has been implemented. This procedure converts a 12-lead signal into a set of R waves by using the detection algorithms and the k-mean algorithm.

/pdf/study-of-the-few-shot-learning-for-ecg-classification-based-1gtrq795.pdf

Damian Ledziński

Papers

Molecular Dynamic Analysis of Hyaluronic Acid and Phospholipid Interaction in Tribological Surgical Adjuvant Design for Osteoarthritis.

Assessing Measurements of QoS for Global Cloud Computing Services

ECG Signal Classification Using Deep Learning Techniques Based on the PTB-XL Dataset.

Anomalous Behavior of Hyaluronan Crosslinking Due to the Presence of Excess Phospholipids in the Articular Cartilage System of Osteoarthritis.

Study of the Few-Shot Learning for ECG Classification Based on the PTB-XL Dataset